Review of Basic Treatment Recommendations

1
Review of Basic Treatment Recommendations
Peripheral arthritis
NSAIDs for mild disease DMARDs and TNF-a inhibitors for moderate or severe disease
Dactylitis
NSAIDs for mild disease but rapid progression to injected corticosteroids not uncommon Infliximab (A-level evidence)
Axial disease (Recommendations derived from AS)
NSAIDs, physiotherapy, analgesia, injection of sacroiliac joint, mild-to-moderate disease TNF-a inhibitors - efficacy demonstrated with infliximab, adalimumab and etanercept in AS consensus for similar efficacy in axial PsA
Enthesitis (Recommendations derived from AS)
NSAIDs, physical therapy, corticosteroids for mild disease DMARDs for moderate disease TNF-a inhibitors for severe disease (A-level evidence)
Skin disease
First-line therapies for moderate or severe disease Methotrexate, cyclosporine, fumaric acid esters, efalizumab TNF-a inhibitors (include etanercept, adalimumab and infliximab) Second- and third-line therapies Acitretin, alefacept Sulfasalazine, leflunomide, hydroxyurea, mycophenolate mofetil, thioguanine
Nail disease
Retinoids, oral PUVA, cyclosporine TNF-a inhibitors (infliximab) Anti-T-cell agents (alefacept)