The Institutional Development Award (IDeA) Program

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The Institutional Development Award (IDeA)
Program
W. Fred Taylor, PH.D. National Institute of
General Medical Science National Institutes
of Health May 25, 2012
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• Program Overview
• Centers of Biomedical Excellence (COBRE)
• Phase I, Phase II, Phase III
• IDeA Clinical and Translational Research (IDeA
  CTR)
• IDeA Networks of Biomedical Research Excellence
  (INBRE)
• IDeA Community-Based Research
• Selected Examples
• IDeA Co-funding
• IDeA Net
• Selected Examples
• National Association of IDeA Principal
  Investigators (NAIPI)
• Selected Science Advances

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Program Overview
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Institutional Development Award Program

• Authorized by Congress, 1993 NIH Revitalization
  Act
• Intent to enhance geographical distribution of
  NIH research funds and increase research capacity
• Currently 23 states and Puerto Rico are IDeA
  eligible
• Similar to NSF Experimental Program to Stimulate
  Competitiveness in Research (EPSCoR, est. 1980)
• Contact W. Fred Taylor, Ph.D.
• taylorwf_at_mail.nih.gov

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Institutional Development Award Program

• Perceived needs to increase research capacity
• Core Laboratories
• Senior and Junior Faculty development
• Infrastructure (equipment)
• Facilities alteration and renovation/development
• Post-doctoral, student and staff development
• Faculty recruitment
• Bioinformatics training for students and faculty
• State of the Art Instrumentation
• Release time for teaching and clinical faculty
• Undergraduate, graduate, post-doctoral
  recruitment
• Training opportunities in grant management

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Institutional Development Award ProgramOverall
Approach

• Faculty development
• Faculty recruitment and start-up
• Funding and release time for research projects
• Mentoring to become successful independent
  investigators
• Enhancement of research facilities
• Core laboratories
• State-of-the-art equipment
• Research education and training
• Graduate students, postdoctoral fellows, research
  staff
• Undergraduate students and faculty

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INBRE 24 statewide networks COBRE 84 thematic
research centers
VT
ME
MT
ND
NH
ID
SD
RI
WY
NE
NV
DE
WV
KS
KY
OK
SC
AR
NM
MS
LA
AK
PR
HI
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Centers of Biomedical Excellence (COBRE) Phase I,
Phase II, Phase III
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Centers of Biomedical Research Excellence (COBRE)
Background

• COBRE center grant program launched in fiscal
  year 2000
• To expand and develop biomedical faculty research
  capability
• To enhance research infrastructure including core
  facilities
• To build multidisciplinary research centers with
  a thematic scientific focus at doctoral
  institutions or research institutes
• Center Characteristics
• Led by an established investigator, funded by
  NIH, NSF or other comparable Federal or private
  sector source
• At least 3 research sub-projects, all supervised
  by junior investigators
• A clear plan for mentoring, career development
  and graduation and replacement of junior
  investigators
• Long-term plans for developing and sustaining the
  center, investigators, collaborations, and
  physical infrastructure

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Model of COBRE
Pilot Projects
External Advisory Board
research cores
bioinformatics
administrative

• Administrative and Research Cores
• workshops
• training courses

Mentored Junior Investigator Subprojects
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COBRE

• Currently three sequential 5 year phases
• Phase I To develop research infrastructure and
  provide junior (new) investigators mentoring and
  project funding so they can successfully compete
  for independent research support
• Phase II To further develop research
  infrastructure and develop a strong critical mass
  of investigators (new, early stage and
  established) with shared scientific interests
• Phase III To maintain COBRE research cores and
  to provide support for research pilot projects
  and mentoring and training

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COBRE
Develop advanced research infrastructure and a
critical mass of investigators in thematic areas
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Centers of Biomedical Research Excellence (COBRE)
Phase III Transitional Centers

• Purpose
• To conduct basic, clinical and translational
  research
• To support essential cores
• To sustain a collaborative, multidisciplinary
  research environment by supporting mentoring and
  training components.
• Center Characteristics
• Administrative Core (mentoring and training
  components and pilot projects)
• Core resources including core supplies, service
  contracts and core management
• Equipment upgrades and replacement

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Summary of COBRE Scientific Themes
Scientific Themes Number of Grants
Neuroscience 18
Cancer 9
Cardiovascular Disease 11
Immunology 9
Proteomics and Genomics 8
Infectious Disease 5
Oral Health 5
Women or Minority Health and Health Disparity (WMHHD) 4
Environmental Science (ES) 2
Muscle Biology (MB) 3
Biochemistry and Biophysics (BB) 2
Drug Discovery and Design (DD) 3
Lung Biology and Disease (LD) 2
Prenatal Biology (PB) 2
Stem Cell Biology (SCB) 3
Bioengineering and Biomaterial 1
SCB
PB
LD
DD
BB
MB
ES
WMHHD
Oral Health
Infectious Disease
Proteomics and Genomic
Immunology
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COBRE Progress

• In fiscal year 2011
• 84 COBRE awards supported 786 research projects
  involving 1482 investigators
• COBRE centers published 1449 articles with an
  additional 603 papers in press
• COBRE investigators made a total of 1882
  scientific presentations

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IDeA Clinical and Translational Research (IDeA
CTR)
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IDeA Program Clinical and Translational Research
Initiative(IDeA CTR)

• Rationale
• A relatively small proportion (10) of
  IDeA-funded centers and networks focus on
  developing clinical and community-based
  translational research capacity
• It is critically important to translate the many
  biomedical research advances from IDeA states
  into better health outcomes by forging
  partnerships between basic and clinical
  scientists in IDeA institutions, supported by
  programs across NIH

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IDeA-CTR

• Objectives
• To support the development of infrastructure and
  human resources required to conduct clinical and
  translational research in IDeA states.
• To enhance the ability of IDeA institutions and
  investigators to develop competitive clinical and
  translational research programs.
• To foster and sustain collaboration and
  coordination of clinical and translational
  activities within and across IDeA institutions
  /organizations.

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IDeA-CTR

• Award mechanism and Total Cost
• U54 cooperative agreement
• Up to 4 million per year for 5 years
• Can request additional 300K for AR costs (year
  1 only)
• Lead Institution
• Academic Health Center
• Only one application per state
• Partnerships
• It is required to identify one or more
  collaborating domestic partner(s) within the
  state and in one other (or more) IDeA state(s).
• Funding Opportunity Announcement IDeA-CTR
  (PAR-11-229)

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Component Activities of IDeA-CTR Program
Key Component Activities (Required)
Partnerships and Collaborations within and across
IDeA-eligible states
Clinical and Translational Pilot Grants Program
Clinical Research Design, Epidemiology, and
Biostatistics Core
Clinical Research Education, Mentoring, and
Career Development Core
Potential Key Component Activities
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IDeA Networks of Biomedical Research Excellence
(INBRE)
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IDeA Networks of Biomedical Research Excellence
(INBRE)

• To develop a statewide multi-disciplinary
  research network of doctoral degree-granting and
  undergraduate institutions
• To build and increase research capacity by
  supporting faculty, fellows and students at
  participating institutions
• To provide bioinformatics tools, training, and
  expertise for researchers and students across the
  network
• To provide undergraduate faculty and students
  research support, serve as pipeline to health
  research careers
• To provide outreach to students at undergraduate
  institutions, community colleges and tribal
  colleges
• To enhance statewide science and technology
  knowledge base

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Model of INBRE
Lead Institution- Research Intensive
Institutions or Institutes
PUI Primarily Undergraduate Institution
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KANSAS-INBRE Organization
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Summary of INBRE Scientific Themes
Scientific Themes Total
Microbiology and Infectious Disease 63
Cell Developmental Biology 46
Cancer 42
Neuroscience 33
Biotechnology 23
Environmental Health Toxicology (EHT) 23
Genetics Genomics (GG) 15
Cardiovascular Disease (CVS) 11
Women Reproductive Health (WRH) 10
Bioinformatics (BI) 9
Others (O) 9
Diabetes/Obesity/Metabolism (DOM) 8
Respiratory (Re) 5
Mental Health Biobehavioral research (MH) 5
Bones/Joints (BJ) 4
Immunology (Im) 3
Hematology (H) 2
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INBRE Progress

• In fiscal year 2011
• 24 INBRE Networks supported 658 research
  subprojects and 1808 investigators
• INBRE Networks published 610 research articles
  with 259 in press
• INBRE investigators made 2561 scientific
  presentations
• 69 INBRE flagship institutions supported 800
  students in summer research experiences
• INBREs supported research and training at 270
  undergraduate institutions including
• 21 HBCUs
• 17 Tribal Colleges and Universities
• 21 Hispanic-serving institutions

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IDeA Community-Based Research
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IDeA Community Based Research (IDeA CBR)

• Goals
• To support development of sustainable,
  culturally appropriate prevention/intervention
  research programs to decrease the
  disproportionate burden of disease
• To develop effective and stimulating environments
  to facilitate training and development of
  clinical investigators in areas of health
  disparities and special populations

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IDeA CBR

• To augment and strengthen translational /
  clinical community based research programs to
  address health disparities in rural and urban
  special populations
• To promote interdisciplinary, multi-site
  collaborations between academic researchers
  across programs, community health care providers,
  and community partners
• To leverage investments in CBPR made by NIH and
  other agency partners

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http//canhr.uaf.edu/
Yupik Perceptions of Body Weight and
Diabetes Cultural Pathways to Prevention   Yupik
Experiences of Stress and Coping Intervention
Via Cultural Understanding   Contaminants and
Nutrients in Alaskan Subsistence Foods Striking
a Balance   Developing a Novel Set of Diet
Pattern Biomarkers Based on Stable Isotope Ratios
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Environmental Health Science in Montana
Analyzing river water and fish on the Crow
Reservation to identify environmental
contaminants - mercury - pesticides -
enteric pathogens
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IDeA Co-funding
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IDeA Co-funding

• IDeA co-funds awards to support R01 grant
  applications to NIH Institutes and Centers from
  investigators within IDeA eligible states.
• IDeA provides support to applicants whose
  proposals received excellent ratings through the
  peer review process but fell short of the
  Institutes or Centers (ICs) pay line.
• IDeA provides 70 or up to 260,000 for each of
  the first two years of a selected co-funded R01
  award.
• This activity was highlighted in the NIH fiscal
  year 2012 appropriation language.

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IDeA Co-funding

• Meritorious applications were solicited from the
  27 NIH Institutes and Centers in fiscal year
  2012.
• IDeA received 44 R01 applications nominated from
  18 NIH Institutes and Centers.
• The total request for IDeA co-funding amounted to
  11.1 million.

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IDeA Net
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IDeANet

• Provides
• Advanced cyberinfrastructure for biomedical and
  behavioral research
• Regional approaches to relieve strategic
  bottlenecks in connectivity through participating
  states
• Access to national high-speed computer networks
  for data-intensive science applications
• Computer hardware and software
• Staff in bioinformatics cores and data centers

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http//www.loni.org/
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Northeast Cyberinfrastructure Consortium (NECC)
Multiple partnerships are formed between state
university systems and private telecommunications
companies to build regional high-speed networks
in VT, NH, ME, RI and DE.
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Cyberinfrastructure-Enabled Research and Training

• A collaborative project for sequencing the skate
  genome was developed between U. of Delaware and
  Mount Desert Island Biological Laboratory (MDIBL)
  .
• Three training workshops of Skate Genome
  Annotation were performed through the network.
  The data are stored on server at the NECC shared
  data center at the U. of Delaware and U. of
  Maine, and available for investigators within the
  five NECC states.
• Research training courses were provided to the
  first year medical students at MDIBL, Dartmouth
  Medical School and U. of Vermont College of
  Medicine.

Skate genome sequence assembly and annotation
project
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Cyberinfrastructure-Enabled Science Education
(Media Release)
MDIBL participated Howard Hughes medical
Institutes Science Education Alliance
Maine INBRE Newsletter
The Bar Harbor Times
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National Association of IDeA Principal
Investigators (NAIPI)
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National Association of IDeA Principal
Investigators (NAIPI)

• Provides leadership and communication for the
  development, promotion and improvement of the
  IDeA Program
• Fosters interactions between the IDeA Program and
  its constituencies
• Promotes resource sharing among IDeA programs
• Enhances the visibility of the IDeA Program
• Develops a consensus on priorities and new
  directions for IDeA
• Identifies and disseminates best practices within
  the IDeA Program
• Identifies opportunities and develops strategies
  to achieve the common goals of the IDeA Program

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National Association of IDeA Principal
Investigators (NAIPI)

• Membership composed of Principal Investigators of
  INBRE and COBRE grants
• National Committee consists of 20 members, five
  for each of four Regional Divisions of IDeA (2
  INBRE and 3 COBRE Principal Investigators)
• National Committee members elected by voting
  members in each division
• Executive Committee consists of 4 members elected
  by the National Committee (President, Vice
  President, Past President and Secretary/Treasurer)
  
• Working groups on an ad hoc basis
• Web-site at http//www.naipi.org

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Selected Science Advances
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Understanding the Role of Estrogen in Protecting
Against HIV Dementia COBRE PI Tom Curry,
University of Kentucky College of Medicine
Background HIV-associated dementia (HAD) occurs
in about 30 of all HIV-infected individuals
despite aggressive anti-retroviral therapy. In
vitro studies indicate that the hormone estrogen
(17ß-estradiol or E2) acts as a neuroprotective
agent by suppressing the production of
HIV-encoded proteins by astrocytes. The role of
estrogen receptors in this process is
unclear. Advance In vitro studies revealed that
astrocytes have low levels of ERa expression.
Surprisingly, the presence of ERa appeared to
negate the reduction in HIV protein production
that results from treatment with estrogen.
Analysis of postmortem brain samples showed
increased density of ERa-positive astrocytes in
HIV-infected individuals with dementia compared
to those without cognitive deficits. The data
suggest that E2 may have the most dramatic effect
in reducing HIV transcription and acting as a
neuroprotective agent early in the disease
process when the subpopulation of astrocytes
expressing ERa is low. How NCRR Grant Enabled
Advance NCRR COBRE grant (P20 RR18727), provided
support to the research project and core
facilities. Public Health Impact Neurological
complications are observed in about 60 of all
HIV infected patients, dementia in about 30
despite anti-retroviral therapy. It is
imperative that effective neuroprotective agents
be developed if neurological complications of HIV
are to be prevented. Publication Citation and
Link http//www.ncbi.nlm.nih.gov/pubmed/19886840
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Mechanisms of Plasticity and Repair after Spinal
Cord Injury PI Scott Whittemore Univ of
Louisville School of Medicine
Background Multiple molecular, biochemical, and
cellular events ensue following traumatic spinal
cord injury (SCI). The prevention and/or
attenuation of significant morbidity following
SCI will require various neuroprotective
strategies. Advance Following experimental
SCI, studies in rats indicate that
transplantation of adult oligodendrocyte
precursor cells (OPCs) that express ciliary
neurotrophic factor (CNTF) resulted in
histological, physiological, and functional
evidence of recovery. Another study demonstrate
that administration of rolipram, an
investigational anti-inflammatory agent, spared
the death of oligodendrocytes, improved
neurotransmission, and reduced hind limb errors
during grid walking. In yet another study, the
administration of agents that promote
angiogenesis and endothelial cell survival had
similar neuroprotective outcomes. How NCRR Grant
Enabled Advance NCRR COBRE grant (P20 RR15576),
provided support to the research project and core
facilities. Public Health Impact Spinal cord
injury (SCI) significantly impacts quality of
life and poses a considerable economic burden on
those afflicted. Restorative therapies need to
be developed to reduce these burdens. Publication
Citation and Link http//www.ncbi.nlm.nih.gov/pu
bmed/20181596 http//www.ncbi.nlm.nih.gov/pubmed/2
0375135, http//www.ncbi.nlm.nih.gov/pubmed/196355
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Community-Based Participatory Research in Indian
Country PI Margaret Eggers, M.S., Little Big
Horn College, Crow Agency, Montana Montana State
University, Bozeman
Background The poor well water quality and
deteriorating river water quality are impacting
community health. The occurrence of disease seems
greater on the tribal reservation than in other
communities. A collaborative research between
Crow Reservation community and academic partners
was initiated to assess the risk of exposure to
contaminants via domestic and cultural water
sources. Advance Little is known about how
communities and academic partners can effectively
work together to conduct community-based risk
assessment, and rarely have Native American
community members written about their perception
of the value of the CBPR process to their
community, why they would participate in such
research, and how research should be conducted in
their home community. The Crow Tribal and
academic research partners describe their
experiences and what they have learned in working
together on a creative, collaborative CBPR
project and process. How NCRR Grant Enabled
Advance The Montana INBRE provided initial
research funding for the first five years of the
project, and continues to support the well water
testing costs. Public Health Impact This
project provides an example of how community
members can initiate a risk assessment research
in collaboration with academic partners. The
partnership improves the quality of the risk
assessment and the effectiveness of dissemination
to community members. Publication Citation.
Community-based participatory research in Indian
country improving health through water quality
research and awareness. Fam Community Health.
2010 Jul-Sep33(3)166-74.
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Institutional Development Award Program
Opportunities for Inclusion