Cardiovascular Health

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Cardiovascular Health
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(No Transcript)
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HEALTHY CARDIOVASCULAR SYSTEM
HEALTHY HEART
HEALTHY ARTERIES
HEALTHY BLOOD PRESSURE
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Globally.

• 17 million people die of cardiovascular disease
  each year.
• In the United States, coronary heart disease is
  the single biggest killer and is responsible for
  1 in every 5 deaths.
• In Europe, cardiovascular disease causes 4
  million deaths each year.
• In Asia, the figure is on the rise.

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In Singapore..

• Heart disease is the No.2 killer after cancer.
• Approximately 2,000 people get heart attack every
  year. Of these 50 die because they do not
  receive medical help fast enough.
• Death rate due to cardiovascular disease was 7.7
  ( 1957 ) to 26.3 ( 2001 ).

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In Singapore..

• Death due to ischaemic disease is 100/100,000
  population.
• United States is 125/ 100,000, Australia
  97/100,000, Japan 22/100,000 and Hong Kong
  40/100,000.

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According to the State of Health 2001 report.

• 27 of Singaporeans are hypertensive.
• 58 are physically inactive during their leisure
  time.
• 24 are overweight with 6 being obese.

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Surveys show that most women are far more afraid
of breast cancer than of cardiovascular disease
(even though 1 in 30 womens deaths is from
breast cancer while 1 in 2.4 is from CVD

• 2002 Heart and Stoke Statistical Update, American
  Heart Association

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MSNBC.com
AN AUTOPSY SHOWED the 33-year-old pitcher had
80-to-90 percent narrowing of two of the three
branches of the coronary artery, Dr. Edmund
Donoghue said Sunday. He said the blockage was
the likely cause of death.
CHICAGO, June 24,2002  Darryl Kile of the St.
Louis Cardinals died.
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CNN.com
Nutrition expert and author Dr. Robert Atkins,
creator of the high-protein/low-carbohydrate
"Atkins Diet," was released Wednesday from
hospital care and is resting well after his heart
stopped, a condition called cardiac arrest.
(Note Latter report stated that the cause was
an cardiovascular infection.)
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The Pathobiological Determinants of
Atherosclerosis in Youth (PDAY)

• Study Group 3000 persons dying of external
  causes
• Atherosclerosis begins in childhood
• By age 15, all subjects had atherosclerosis

• McGill HC Jr, McMahan CA, Herderick EE, Zieske
  AW, Malcom GT, Tracy RE, Strong JP Circulation
  2002 Jun 11105(23)2712-8. Comment in
  Circulation. 2002 Jun 11105(23)2696-8.
• Zieske AW, Malcom GT, Strong JP. Natural history
  and risk factors of atherosclerosis in children
  and youth the PDAY study. Pediatr Pathol Mol
  Med 2002 Mar-Apr21(2)213-37
• Strong JP, Zieske AW, Malcom GT. Lipoproteins
  and atherosclerosis in children an early
  marriage? Nutr Metab Cardiovasc Dis 2001 Oct11
  Suppl 516-22

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Estimated Direct and Indirect Costs of
Cardiovascular Diseases and Stroke United
States 2002
2002 Heart and Stroke Statistical Update,
American Heart Association
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As recently as five years ago, most physicians
would have confidently described atherosclerosis
as a straight plumbing problem.

• Scientific American May, 2002 pg. 48

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AtherosclerosisThe NEW VIEW

• The long held conception of how the disease
  develops turns out to be wrong.
• Not a straight plumbing problem!
• Inflammation fuels the development and
  progression of Atherosclerosis

• Peter Libby Scientific American May 2002, p 47-55.

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Habitual response to events as if they were
life-threatening generates a repetitive
stress/inflammatory response that may result in
atherosclerosis

• Black PH, Garbutt LD. Stress, inflamation and
  cardiovascular disease. J Psychosomatic Res
  2002, 52, 1-23.

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CVD Why does it happen?

• Balance and Compensation
• Hierarchy of Health
• Adaptation and Disadaptaion
• Damage and Repair

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CVD How does it happen?

• Infections can inflame arteries and lead
  to heart attacks
• Six microbes associated with CVD risk
• Cytomegalovirus
• Hepatitis A
• Herpes Simplex viruses 1 and 2
• Chlamydia pneumoniae
• H. Pylori

• American College of Cardiology March 2000

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Dave Getting the Idea
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Targeted Transfer Factor

• Managed environment
• Unfertilized eggs

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Egg Allergies

• Prevalence of probable food allergy
• 0.61 for peanut.
• 0.53 shrimp
• lt0.27 for wheat
• 0.09 for cow's milk and egg
• Main egg allergens are found in whites

• Woods RK, Thien F, Raven J, Walters EH, Abramson
  M. Prevalence of food allergies in young adults
  and their relationship to asthma, nasal
  allergies, and eczema. Ann Allergy Asthma
  Immunol 2002 Feb88(2)183-9
• Anet J, Back JF, Baker RS, Barnett D, Burley RW,
  Howden ME. Allergens in the white and yolk of
  hen's egg. A study of IgE binding by egg
  proteins. Int Arch Allergy Appl Immunol
  198577(3)364-71

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Magnesium

• Magnesium deficiency has been shown to correlate
  with a number of chronic cardiovascular diseases,
  including hypertension, diabetes mellitus, and
  hyperlipidemia.

Fox C, Ramsoomair D, and Carter C. South Med J
2001 94(12) 1195-20. Abstract.
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Magnesium

• The American diet is low in magnesium, and with
  modern water systems, very little is ingested in
  the drinking water.

Innerarity S. Crit Care Nurs 2000 23(2) 1-19.
Abstract.
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Magnesium

• Allows blood vessels to relax not spasm
• Required for metabolic efficiency
• Deficiency leads to hypertrophy or enlargement of
  the heart
• Magnesium is a NATURAL calcium channel blocker (1)

1. Stigson, L. and I. Kjellmer (1997). "Serum levels
   of MAGNESIUM at birth related to complications of
   immaturity." Acta Paediatr 86(9) 991-4.
2. Med Text refs

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Dietary Copper Deficiency

• high blood pressure
• enhancement of inflammation
• anemia
• reduced blood clotting
• arteriosclerosis

• Saari JT and Schuschke DA. Biofactors 1999
  10(4) 359-75.

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Zinc

• Zinc requirements
• of the vascular
• endothelium
• are increased
• during inflammatory conditions
• such as atherosclerosis.

Hennig B, Meerarani P, et al. Br J Nutr 1999
81(2) 85-6.
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Zinc

• Both men and women who took zinc supplements had
  higher HDL cholesterol levels than non
  supplementing individuals.

• Neggers YH, Bindon JR, et al. Biol trace Elem
  Res 2001 79(1) 1-13.

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Selenium

• Selenium deficiency leads to an increased
  frequency of cardiovascular diseases.
• Selenium is well recognized as a preventive
  factor for cancer and cardiovascular diseases.

Racek J, Holecek V, et al. Vnitr Lek 1999
45(6) 373-8. Miyazaki Y, Koyama H, et al.
Nippon Koshu Eisei Zasshi 2001 48(4) 243-57.
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Hyperhomocysteinemia

• Elevated levels of homocysteine promote the
  development of atherosclerosis.

• Approximately 10 of coronary artery disease
  cases are attributable to hyperhomocysteinemia.
• Folic Acid ? -25 homocysteine
• Vit B12 ? -7 homocysteine

Zacarias-Castillo R, Hernandez-Rebollar AE, et
al. Gac Med Mex 2001 137(4) 335-45. Ubbink JB,
Becker PJ, Vermaak WJ. Nutr Rev 1996 54(7)
213-6. Clarke R, Armitage J. Semin Thromb Hemost
2000 26(3)341-8. Auer J, Berent R, et al.
Wien Med Wochenschr 2001151(1-2)25-8.
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Vitamin C

• Antioxidants, such as vitamin C, may slow
  atherogenesis.
• An increased intake of vitamin C is associated
  with a reduced risk of chronic diseases such as
  cancer, cardiovascular disease, and cataracts

• Price KD, Price CS, et al. Atherosclerosis 2001
  158(1)1-12.
• Carr AC and Frei B. Am J Clin Nutr 1999 69(6)
  1086-107.

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Vitamin E Supplement Benefits

• Decreased cardiac events
• U.S. Nurses Health Study
• - 34 risk reduction
• U.S. Health Professionals Study
• - 39 risk reduction
• Iowa Womens Health Study
• - 47 mortality reduction
• Cambridge Heart Antioxidant Study
• - 47 infarct reduction

Emmert DH, Kirchner JT. Arch Fam Med 1999 8(6)
537-42. Abstract.
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Lysine and Herpes

• Herpes group viruses, especially cytomegalovirus
  and herpes simplex virus type 1, have been
  associated with both atherosclerosis and
  restenosis. (1)
• L-Lysine monohydrochloride is used as a
  suppressant of recurrent herpes simplex
  infections. (2)

• (1) Leinonen M, Saikku P. Scand Cardiovasc J
  2000 34(1) 12-20.
• (2) Flodin, NW. J Am Coll Nutr 1997 16(1) 7-21.

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A critical balance between relaxing and
contracting factors
atherosclerotic arteries ? paradoxical
vasoconstriction.

• Verma S, Anderson T. Fundamentals of endothelial
  function for the clinical cardiologist.
  Circulation 2002, 105, 546-549.
• Libby P. Current concepts of the pathogenesis of
  acute coronary syndromes. Circulation 2001, 104,
  365-372.

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Arginine NO

• Nitric oxide is a relaxing factor
• L-Arginine is the precursor for nitric oxide
  (NO).
• Oral L-Arginine supplementation can improve
  symptoms of cardiovascular disease.
• (Note Magnesium is also critical.)

• Wu G, Meininger CJ. J Nutr 2000 130(11) 2626-9.
• Boger RH, Bode-Boger SM. Annu Rev Pharmacol
  Toxicol 20014179-99.

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Resveratrol

• Antioxidant,
• Promote nitric oxide production,
• Inhibit platelet aggregation,
• Increase high-density lipoprotein (HDL)
  cholesterol,
• Cardioprotective agent.

• Bhat KPL, Kosmeder JW, 2nd. Antioxid Redox Signal
  2001 2(6) 1041-64.

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Coenzyme Q10

• Useful in congestive heart failure, angina
  pectoris, cardiomyopathy, coronary artery disease
  and in the preservation of myocardium.
• Coenzyme Q10 is normally found in LDL cholesterol
  and it inhibits its oxidation.
• Cardiac levels of Coenzyme Q10 were decreased in
  heart disease.

• Singh RB, Niaz MA, et al. J Assoc Physicians
  India 1998 46(3) 299-306.
• Kucharska J, Gvozdjakova A, et al. Bratisl Lek
  Listy 1996 97(6) 351-4.

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Red Yeast Rice

• Reduces
• total cholesterol,
• LDL cholesterol, and
• total triacylglycerol concentrations
• Provides a new, novel, food-based approach to
  lowering cholesterol in the general population.

• Heber D, Yip I, et al. Am J Clin Nutr 1999
  69(2) 231-6.

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Cardio Herbs

• Hawthorne
• Salt Balance, Vessel Integrity
• Ginkgo Biloba
• Antioxidant, stabilizer
• Garlic
• Antimicrobial, Antioxidant

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SUMMARY of the Problem

• CVD is the 1 Killer
• CVD Starts Early
• CVD is NOT a Simple Plumbing Problem
• The Immune System is Critically Involved in CVD
• Infection may Initiate CVD
• Metabolic Toxins and Chronic Stress Can Trigger
  Chronic Inflammation

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Summary of a Solution

• Control Infection
• Control Inflammation
• Help the Blood Vessels Relax
• Protect the Heart and Arteries from Toxin and
  Oxidative Damage
• Increase the Pumping Efficiency of the Heart

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Summary of TFCardio1

• Tune the Immune System
• Targeted TF, Zn, Lysine
• Help relax the Blood Vessels
• Arginine, Mg, Ginko, Hawthorne, Butchers Broom
• Help support the Pumping Efficiency of the Heart
• Mg, CoQ10

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Summary of TFCardio2

• Help block Oxidative Damage
• Se, Cu/Zn
• Beta carotene, Vit C, Vit E, Resveratrol,
• Help improve Toxin Clearance
• Folic Acid, Vit B6 and Vit B12
• Help maintain Cholesterol Balance
• Red Rice Yeast, Garlic