Title: G IN A
1G INA
lobal itiative for sthma
2GINA Program Objectives
- Increase appreciation of asthma as a global
public health problem - Present key recommendations for diagnosis and
management of asthma - Provide strategies to adapt recommendations to
varying health needs, services, and resources - Identify areas for future investigation of
particular significance to the global community
3Executive CommitteeChair Paul OByrne, MD
GINA Structure
Dissemination/Implementation Task Group Chair
Wan Tan, MD
Science Committee Chair Eric Bateman, MD
4GINA Executive Committee
- P. OByrne, Chair, Canada
- E. Bateman, S. Africa S. Pedersen, Denmark
- J. Bousquet, France R. Singh, India
- T. Clark, UK M. Soto-Quiroz, Costa Rica
- K. Ohta, Japan W. Tan, Canada
- P. Paggario, Italy
-
5GINA Science Committee
- E. Bateman, Chair, S. Africa
- P. Barnes, UK K. Ohta, Japan
- J. Bousquet, France S. Pedersen, Denmark
- J. Drazen, US E. Pizzichini, Brazil
- M. FitzGerald, Canada S. Sullivan, US
- P. Gibson, Australia S. Wenzel, US
- P. OByrne, Canada H. Zar, S. Africa
6Executive CommitteeChair Paul OByrne, MD
GINA Structure
Science Committee Chair Eric Bateman, MD
Dissemination/Implementation Task Group Chair
Wan Tan, MD
GINA ASSEMBLY
7GINA Assembly
- A network of individuals participating in the
dissemination and implementation of asthma
management programs at the local, national and
regional level - GINA Assembly members are invited to meet with
the GINA Executive Committee during the ATS and
ERS meetings -
8Bangladesh
Saudi Arabia
Slovenia
Germany
Ireland
Yugoslavia
Australia
Croatia
Canada
Brazil
Austria
Taiwan ROC
United States
Portugal
Thailand
Malta
Greece
Moldova
Mexico
China
Syria
South Africa
United Kingdom
Hong Kong
New Zealand
Italy
Chile
Venezuela
Argentina
Israel
Lebanon
Pakistan
Japan
GINA Assembly
Korea
Poland
Netherlands
Switzerland
Georgia
Russia
Macedonia
France
Czech Republic
Denmark
Turkey
Slovakia
Belgium
Singapore
Spain
Colombia
Ukraine
Romania
India
Sweden
Vietnam
Kyrgyzstan
Albania
9GINA Documents
- Global Strategy for Asthma Management and
Prevention (revised 2006) - Pocket Guide Asthma Management and Prevention
(revised 2006) - Pocket Guide Asthma Management and Prevention in
Children (revised 2006) - Guide for asthma patients and families
- All materials are available on GINA web site
www.ginasthma.org
10Global Strategy for Asthma Management and
Prevention
- Evidence-based
- Implementation oriented
- Diagnosis
- Management
- Prevention
- Outcomes can be evaluated
11Global Strategy for Asthma Management and
Prevention
- Evidence Category Sources of Evidence
- A Randomized clinical trials
- Rich body of data
-
- B Randomized clinical trials
- Limited body of data
-
- C Non-randomized trials
- Observational studies
-
- D Panel judgment consensus
12Global Strategy for Asthma Management and
Prevention (2006)
- Definition and Overview
- Diagnosis and Classification
- Asthma Medications
- Asthma Management and Prevention Program
- Implementation of Asthma Guidelines in Health
Systems
Revised 2006
13Definition of Asthma
- A chronic inflammatory disorder of the airways
- Many cells and cellular elements play a role
- Chronic inflammation is associated with airway
hyperresponsiveness that leads to recurrent
episodes of wheezing, breathlessness, chest
tightness, and coughing - Widespread, variable, and often reversible
airflow limitation
14Asthma Inflammation Cells and Mediators
Source Peter J. Barnes, MD
15Mechanisms Asthma Inflammation
16Asthma Inflammation Cells and Mediators
Source Peter J. Barnes, MD
17Burden of Asthma
- Asthma is one of the most common chronic diseases
worldwide with an estimated 300 million affected
individuals - Prevalence increasing in many countries,
especially in children - A major cause of school/work absence
18Burden of Asthma
- Health care expenditures very high
- Developed economies might expect to spend 1-2
percent of total health care expenditures on
asthma. Developing economies likely to face
increased demand - Poorly controlled asthma is expensive investment
in prevention medication likely to yield cost
savings in emergency care
19Asthma Prevalence and Mortality
Source Masoli M et al. Allergy 2004
20Countries should enter their own data on burden
of asthma.
21Risk Factors for Asthma
- Host factors predispose individuals to, or
protect them from, developing asthma - Environmental factors influence susceptibility
to development of asthma in predisposed
individuals, precipitate asthma exacerbations,
and/or cause symptoms to persist
22Factors that Exacerbate Asthma
- Allergens
- Respiratory infections
- Exercise and hyperventilation
- Weather changes
- Sulfur dioxide
- Food, additives, drugs
23Factors that Influence Asthma Development and
Expression
- Host Factors
- Genetic
- - Atopy
- - Airway hyperresponsiveness
- Gender
- Obesity
- Environmental Factors
- Indoor allergens
- Outdoor allergens
- Occupational sensitizers
- Tobacco smoke
- Air Pollution
- Respiratory Infections
- Diet
24Is it Asthma?
- Recurrent episodes of wheezing
- Troublesome cough at night
- Cough or wheeze after exercise
- Cough, wheeze or chest tightness after exposure
to airborne allergens or pollutants - Colds go to the chest or take more than 10 days
to clear
25Asthma Diagnosis
- History and patterns of symptoms
- Measurements of lung function
- - Spirometry
- - Peak expiratory flow
- Measurement of airway responsiveness
- Measurements of allergic status to identify risk
factors - Extra measures may be required to diagnose asthma
in children 5 years and younger and the elderly
26Typical Spirometric (FEV1) Tracings
Volume
FEV1
Normal Subject
Asthmatic (After Bronchodilator)
Asthmatic (Before Bronchodilator)
1
2
3
4
5
Time (sec)
Note Each FEV1 curve represents the highest of
three repeat measurements
27Measuring Variability of Peak Expiratory Flow
28Measuring Airway Responsiveness
29Clinical Control of Asthma
- No (or minimal) daytime symptoms
- No limitations of activity
- No nocturnal symptoms
- No (or minimal) need for rescue medication
- Normal lung function
- No exacerbations
- _________
- Minimal twice or less per week
30Levels of Asthma Control
Characteristic Controlled (All of the following) Partly controlled(Any present in any week) Uncontrolled
Daytime symptoms None (2 or less / week) More than twice / week 3 or more features of partly controlled asthma present in any week
Limitations of activities None Any 3 or more features of partly controlled asthma present in any week
Nocturnal symptoms / awakening None Any 3 or more features of partly controlled asthma present in any week
Need for rescue / reliever treatment None (2 or less / week) More than twice / week 3 or more features of partly controlled asthma present in any week
Lung function (PEF or FEV1) Normal lt 80 predicted or personal best (if known) on any day 3 or more features of partly controlled asthma present in any week
Exacerbation None One or more / year 1 in any week One or more / year 1 in any week
31Asthma Management and Prevention Program Five
Components
1. Develop Patient/Doctor Partnership 2. Identify
and Reduce Exposure to Risk Factors 3. Assess,
Treat and Monitor Asthma 4. Manage Asthma
Exacerbations 5. Special Considerations
32Asthma Management and Prevention Program Five
Interrelated Components
1. Develop Patient/Doctor Partnership 2. Identify
and Reduce Exposure to Risk Factors 3.
Assess, Treat and Monitor Asthma 4. Manage Asthma
Exacerbations 5. Special Considerations
33Asthma Management and Prevention Program Goals of
Long-term Management
- Achieve and maintain control of symptoms
- Maintain normal activity levels, including
exercise - Maintain pulmonary function as close to normal
levels as possible - Prevent asthma exacerbations
- Avoid adverse effects from asthma medications
- Prevent asthma mortality
34.
Asthma Management and Prevention Program
- Asthma can be effectively controlled in most
patients by intervening to suppress and reverse
inflammation as well as treating
bronchoconstriction and related symptoms - Early intervention to stop exposure to the risk
factors that sensitized the airway may help
improve the control of asthma and reduce
medication needs.
35Asthma Management and Prevention Program
- Although there is no cure for asthma, appropriate
management that includes a partnership between
the physician and the patient/family most often
results in the achievement of control
36Asthma Management and Prevention
ProgramComponent 1 Develop Patient/Doctor
Partnership
- Guidelines on asthma management should be
available but adapted and adopted for local use
by local asthma planning teams - Clear communication between health care
professionals and asthma patients is key to
enhancing compliance
37Asthma Management and Prevention
ProgramComponent 1 Develop Patient/Doctor
Partnership
- Educate continually
- Include the family
- Provide information about asthma
- Provide training on self-management skills
- Emphasize a partnership among health care
providers, the patient, and the patients family
38Asthma Management and Prevention
ProgramComponent 1 Develop Patient/Doctor
Partnership
- Key factors to facilitate communication
- Friendly demeanor
- Interactive dialogue
- Encouragement and praise
- Provide appropriate information
- Feedback and review
39Example Of Contents Of An Action Plan To Maintain Asthma Control
Your Regular Treatment 1. Each day take ___________________________ 2. Before exercise, take _____________________ WHEN TO INCREASE TREATMENT Assess your level of Asthma Control In the past week have you had Daytime asthma symptoms more than 2 times ? No Yes Activity or exercise limited by asthma? No Yes Waking at night because of asthma? No Yes The need to use your rescue medication more than 2 times? No Yes If you are monitoring peak flow, peak flow less than________? No Yes If you answered YES to three or more of these questions, your asthma is uncontrolled and you may need to step up your treatment. HOW TO INCREASE TREATMENT STEP-UP your treatment as follows and assess improvement every day ____________________________________________ Write in next treatment step here Maintain this treatment for _____________ days specify number WHEN TO CALL THE DOCTOR/CLINIC. Call your doctor/clinic _______________ provide phone numbers If you dont respond in _________ days specify number ______________________________ optional lines for additional instruction EMERGENCY/SEVERE LOSS OF CONTROL ?If you have severe shortness of breath, and can only speak in short sentences, ?If you are having a severe attack of asthma and are frightened, ?If you need your reliever medication more than every 4 hours and are not improving. 1. Take 2 to 4 puffs ___________ reliever medication 2. Take ____mg of ____________ oral glucocorticosteroid 3. Seek medical help Go to _____________________ Address___________________ Phone _______________________ 4. Continue to use your _________reliever medication until you are able to get medical help.
40Asthma Management and Prevention ProgramFactors
Involved in Non-Adherence
- Medication Usage
- Difficulties associated with inhalers
- Complicated regimens
- Fears about, or actual side effects
- Cost
- Distance to pharmacies
- Non-Medication Factors
- Misunderstanding/lack of information
- Fears about side-effects
- Inappropriate expectations
- Underestimation of severity
- Attitudes toward ill health
- Cultural factors
- Poor communication
41Asthma Management and Prevention
Program Component 2 Identify and Reduce
Exposure to Risk Factors
- Measures to prevent the development of asthma,
and asthma exacerbations by avoiding or reducing
exposure to risk factors should be implemented
wherever possible. - Asthma exacerbations may be caused by a variety
of risk factors allergens, viral infections,
pollutants and drugs. - Reducing exposure to some categories of risk
factors improves the control of asthma and
reduces medications needs.
42Asthma Management and Prevention
Program Component 2 Identify and Reduce
Exposure to Risk Factors
- Reduce exposure to indoor allergens
- Avoid tobacco smoke
- Avoid vehicle emission
- Identify irritants in the workplace
- Explore role of infections on asthma development,
especially in children and young infants
43Asthma Management and Prevention
Program Influenza Vaccination
- Influenza vaccination should be provided to
patients with asthma when vaccination of the
general population is advised - However, routine influenza vaccination of
children and adults with asthma does not appear
to protect them from asthma exacerbations or
improve asthma control
44Asthma Management and Prevention
ProgramComponent 3 Assess, Treat and Monitor
Asthma
- The goal of asthma treatment, to achieve and
maintain clinical control, can be achieved in a
majority of patients with a pharmacologic
intervention strategy developed in partnership
between the patient/family and the health care
professional
45Asthma Management and Prevention
ProgramComponent 3 Assess, Treat and Monitor
Asthma
- Depending on level of asthma control, the patient
is assigned to one of five treatment steps - Treatment is adjusted in a continuous cycle
driven by changes in asthma control status. The
cycle involves - - Assessing Asthma Control
- - Treating to Achieve Control
- - Monitoring to Maintain Control
46Asthma Management and Prevention
ProgramComponent 3 Assess, Treat and Monitor
Asthma
- A stepwise approach to pharmacological therapy is
recommended - The aim is to accomplish the goals of therapy
with the least possible medication - Although in many countries traditional methods of
healing are used, their efficacy has not yet been
established and their use can therefore not be
recommended
47Asthma Management and Prevention
ProgramComponent 3 Assess, Treat and Monitor
Asthma
- The choice of treatment should be guided by
- Level of asthma control
- Current treatment
- Pharmacological properties and availability
of the various forms of asthma treatment - Economic considerations
- Cultural preferences and differing health care
- systems need to be considered
48Levels of Asthma Control
Characteristic Controlled Partly controlled(Any present in any week) Uncontrolled
Daytime symptoms None (2 or less / week) More than twice / week 3 or more features of partly controlled asthma present in any week
Limitations of activities None Any 3 or more features of partly controlled asthma present in any week
Nocturnal symptoms / awakening None Any 3 or more features of partly controlled asthma present in any week
Need for rescue / reliever treatment None (2 or less / week) More than twice / week 3 or more features of partly controlled asthma present in any week
Lung function (PEF or FEV1) Normal lt 80 predicted or personal best (if known) on any day 3 or more features of partly controlled asthma present in any week
Exacerbation None One or more / year 1 in any week One or more / year 1 in any week
49Asthma Management and Prevention
ProgramComponent 3 Assess, Treat and Monitor
Asthma
- The choice of treatment should be guided by
- Level of asthma control
- Current treatment
- Pharmacological properties and availability
of the various forms of asthma treatment - Economic considerations
- Cultural preferences and differing health care
- systems need to be considered
50Component 4 Asthma Management and Prevention
Program Controller Medications
- Inhaled glucocorticosteroids
- Leukotriene modifiers
- Long-acting inhaled ß2-agonists
- Systemic glucocorticosteroids
- Theophylline
- Cromones
- Long-acting oral ß2-agonists
- Anti-IgE
- Systemic glucocorticosteroids
51Estimate Comparative Daily Dosages for Inhaled
Glucocorticosteroids by Age
Drug Low Daily
Dose (?g) Medium Daily Dose (?g) High
Daily Dose (?g)
gt 5 y Age lt 5 y gt 5 y Age
lt 5 y gt 5 y Age lt 5 y
Beclomethasone 200-500 100-200 gt500-1000 gt200-400 gt1000 gt400
Budesonide 200-600 100-200 600-1000 gt200-400 gt1000 gt400
Budesonide-Neb Inhalation Suspension 250-500 gt500-1000 gt1000
Ciclesonide 80 160 80-160 gt160-320 gt160-320 gt320-1280 gt320
Flunisolide 500-1000 500-750 gt1000-2000 gt750-1250 gt2000 gt1250
Fluticasone 100-250 100-200 gt250-500 gt200-500 gt500 gt500
Mometasone furoate 200-400 100-200 gt 400-800 gt200-400 gt800-1200 gt400
Triamcinolone acetonide 400-1000 400-800 gt1000-2000 gt800-1200 gt2000 gt1200
52Component 4 Asthma Management and Prevention
Program Reliever Medications
- Rapid-acting inhaled ß2-agonists
- Systemic glucocorticosteroids
- Anticholinergics
- Theophylline
- Short-acting oral ß2-agonists
53Component 4 Asthma Management and Prevention
Program Allergen-specific Immunotherapy
- Greatest benefit of specific immunotherapy using
allergen extracts has been obtained in the
treatment of allergic rhinitis - The role of specific immunotherapy in asthma is
limited - Specific immunotherapy should be considered only
after strict environmental avoidance and
pharmacologic intervention, including inhaled
glucocorticosteroids, have failed to control
asthma - Perform only by trained physician
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57Treating to Achieve Asthma Control
- Step 1 As-needed reliever medication
- Patients with occasional daytime symptoms of
short duration - A rapid-acting inhaled ß2-agonist is the
recommended reliever treatment (Evidence A) - When symptoms are more frequent, and/or worsen
periodically, patients require regular controller
treatment (step 2 or higher)
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59Treating to Achieve Asthma Control
- Step 2 Reliever medication plus a single
controller - A low-dose inhaled glucocorticosteroid is
recommended as the initial controller treatment
for patients of all ages (Evidence A) - Alternative controller medications include
leukotriene modifiers (Evidence A) appropriate
for patients unable/unwilling to use inhaled
glucocorticosteroids
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61Treating to Achieve Asthma Control
- Step 3 Reliever medication plus one or two
controllers - For adults and adolescents, combine a low-dose
inhaled glucocorticosteroid with an inhaled
long-acting ß2-agonist either in a combination
inhaler device or as separate components
(Evidence A) - Inhaled long-acting ß2-agonist must not be used
as monotherapy - For children, increase to a medium-dose inhaled
glucocorticosteroid (Evidence A)
62Treating to Achieve Asthma Control
- Additional Step 3 Options for Adolescents and
Adults - Increase to medium-dose inhaled
glucocorticosteroid (Evidence A) - Low-dose inhaled glucocorticosteroid combined
with leukotriene modifiers (Evidence A) - Low-dose sustained-release theophylline (Evidence
B)
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64Treating to Achieve Asthma Control
- Step 4 Reliever medication plus two or more
controllers - Selection of treatment at Step 4 depends on prior
selections at Steps 2 and 3 - Where possible, patients not controlled on Step 3
treatments should be referred to a health
professional with expertise in the management of
asthma
65Treating to Achieve Asthma Control
- Step 4 Reliever medication plus two or more
controllers - Medium- or high-dose inhaled glucocorticosteroid
combined with a long-acting inhaled ß2-agonist
(Evidence A) - Medium- or high-dose inhaled glucocorticosteroid
combined with leukotriene modifiers (Evidence A) - Low-dose sustained-release theophylline added to
medium- or high-dose inhaled glucocorticosteroid
combined with a long-acting inhaled ß2-agonist
(Evidence B)
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67Treating to Achieve Asthma Control
- Step 5 Reliever medication plus additional
controller options - Addition of oral glucocorticosteroids to other
controller medications may be effective (Evidence
D) but is associated with severe side effects
(Evidence A) - Addition of anti-IgE treatment to other
controller medications improves control of
allergic asthma when control has not been
achieved on other medications (Evidence A)
68Treating to Maintain Asthma Control
- When control as been achieved, ongoing monitoring
is essential to - - maintain control
- - establish lowest step/dose treatment
- Asthma control should be monitored by the health
care professional and by the patient
69Treating to Maintain Asthma Control
Stepping down treatment when asthma is controlled
- When controlled on medium- to high-dose inhaled
glucocorticosteroids 50 dose reduction at 3
month intervals (Evidence B) - When controlled on low-dose inhaled
glucocorticosteroids switch to once-daily
dosing (Evidence A)
70Treating to Maintain Asthma Control
Stepping down treatment when asthma is controlled
- When controlled on combination inhaled
glucocorticosteroids and long-acting inhaled
ß2-agonist, reduce dose of inhaled
glucocorticosteroid by 50 while continuing the
long-acting ß2-agonist (Evidence B) - If control is maintained, reduce to low-dose
inhaled glucocorticosteroids and stop long-acting
ß2-agonist (Evidence D)
71Treating to Maintain Asthma Control
Stepping up treatment in response to loss of
control
- Rapid-onset, short-acting or long-acting inhaled
ß2-agonist bronchodilators provide temporary
relief. - Need for repeated dosing over more than one/two
days signals need for possible increase in
controller therapy
72Treating to Maintain Asthma Control
Stepping up treatment in response to loss of
control
- Use of a combination rapid and long-acting
inhaled ß2-agonist (e.g., formoterol) and an
inhaled glucocorticosteroid (e.g., budesonide) in
a single inhaler both as a controller and
reliever is effecting in maintaining a high level
of asthma control and reduces exacerbations
(Evidence A) - Doubling the dose of inhaled glucocortico-steroids
is not effective, and is not recommended
(Evidence A)
73Asthma Management and Prevention
ProgramComponent 3 Assess, Treat and Monitor
Asthma Children 5 Years and Younger
- Childhood and adult asthma share the same
underlying mechanisms. However, because of
processes of growth and development, effects of
asthma treatments in children differ from those
in adults.
74Asthma Management and Prevention
ProgramComponent 3 Assess, Treat and Monitor
Asthma Children 5 Years and Younger
- Many asthma medications (e.g.
glucocorticosteroids, ß2- agonists, theophylline)
are metabolized faster in children than in
adults, and younger children tend to metabolize
medications faster than older children
75Asthma Management and Prevention
ProgramComponent 3 Assess, Treat and Monitor
Asthma Children 5 Years and Younger
- Long-term treatment with inhaled
glucocorticosteroids has not been shown to be
associated with any increase in osteoporosis or
bone fracture - Studies including a total of over 3,500 children
treated for periods of 1 13 years have found no
sustained adverse effect of inhaled
glucocorticosteroids on growth
76Asthma Management and Prevention
ProgramComponent 3 Assess, Treat and Monitor
Asthma Children 5 Years and Younger
- Rapid-acting inhaled ß2-agonists are the most
effective reliever therapy for children - These medications are the most effective
bronchodilators available and are the treatment
of choice for acute asthma symptoms
77Asthma Management and Prevention
ProgramComponent 4 Manage Asthma Exacerbations
- Exacerbations of asthma are episodes of
progressive increase in shortness of breath,
cough, wheezing, or chest tightness - Exacerbations are characterized by decreases in
expiratory airflow that can be quantified and
monitored by measurement of lung function (FEV1
or PEF) - Severe exacerbations are potentially
life-threatening and treatment requires close
supervision
78Asthma Management and Prevention
ProgramComponent 4 Manage Asthma Exacerbations
- Treatment of exacerbations depends on
- The patient
- Experience of the health care professional
- Therapies that are the most effective for the
particular patient - Availability of medications
- Emergency facilities
79Asthma Management and Prevention
ProgramComponent 4 Manage Asthma Exacerbations
- Primary therapies for exacerbations
- Repetitive administration of rapid-acting inhaled
ß2-agonist - Early introduction of systemic glucocorticosteroid
s - Oxygen supplementation
- Closely monitor response to treatment with serial
- measures of lung function
80Asthma Management and Prevention ProgramSpecial
Considerations
- Special considerations are required to
- manage asthma in relation to
- Pregnancy
- Surgery
- Rhinitis, sinusitis, and nasal polyps
- Occupational asthma
- Respiratory infections
- Gastroesophageal reflux
- Aspirin-induced asthma
- Anaphylaxis and Asthma
81Asthma Management and Prevention Program Summary
- Asthma can be effectively controlled in most
patients by intervening to suppress and reverse
inflammation as well as treating
bronchoconstriction and related symptoms - Although there is no cure for asthma, appropriate
management that includes a partnership between
the physician and the patient/family most often
results in the achievement of control
82Asthma Management and Prevention Program Summary
- A stepwise approach to pharmacologic therapy is
recommended. The aim is to accomplish the goals
of therapy with the least possible medication - The availability of varying forms of treatment,
cultural preferences, and differing health care
systems need to be considered
83http//www.ginasthma.org
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85Alternate Slides for Asthma Treatment
86Levels of Asthma Control
Characteristic Controlled (All of the following) Partly Controlled (Any measure present in any week) Uncontrolled
Daytime symptoms None (twice or less/week) More than twice/week Three or more features of partly controlled asthma present in any week
Limitations of activities None Any Three or more features of partly controlled asthma present in any week
Nocturnal symptoms/awakening None Any Three or more features of partly controlled asthma present in any week
Need for reliever/ rescue treatment None (twice or less/week) More than twice/week Three or more features of partly controlled asthma present in any week
Lung function (PEF or FEV1) Normal lt 80 predicted or personal best (if known) Three or more features of partly controlled asthma present in any week
Exacerbations None One or more/year One in any week
Any exacerbation should prompt review of
maintenance treatment to ensure that it is
adequate. By definition, an exacerbation in any
week makes that an uncontrolled asthma week.
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91Asthma Control Treatment Steps Children Older
than Five Years, Adolescents, Adults
92Example Of Contents Of An Action Plan To Maintain Asthma Control
Your Regular Treatment 1. Each day take ___________________________ 2. Before exercise, take _____________________ WHEN TO INCREASE TREATMENT Assess your level of Asthma Control In the past week have you had Daytime asthma symptoms more than 2 times ? No Yes Activity or exercise limited by asthma? No Yes Waking at night because of asthma? No Yes The need to use your rescue medication more than 2 times? No Yes If you are monitoring peak flow, peak flow less than________? No Yes If you answered YES to three or more of these questions, your asthma is uncontrolled and you may need to step up your treatment. HOW TO INCREASE TREATMENT STEP-UP your treatment as follows and assess improvement every day ____________________________________________ Write in next treatment step here Maintain this treatment for _____________ days specify number WHEN TO CALL THE DOCTOR/CLINIC. Call your doctor/clinic _______________ provide phone numbers If you dont respond in _________ days specify number ______________________________ optional lines for additional instruction EMERGENCY/SEVERE LOSS OF CONTROL ?If you have severe shortness of breath, and can only speak in short sentences, ?If you are having a severe attack of asthma and are frightened, ?If you need your reliever medication more than every 4 hours and are not improving. 1. Take 2 to 4 puffs ___________ reliever medication 2. Take ____mg of ____________ oral glucocorticosteroid 3. Seek medical help Go to _____________________ Address___________________ Phone _______________________ 4. Continue to use your _________reliever medication until you are able to get medical help.