????????? Acetylholine alfa, beta

1
?????? ???????

• ??? ?????????
• ?????????
  ?????????
• ????? ????????? ????????? ?????????
• ????? (???)
• ??????????????? ???????????

2
???????????

• ????????? Acetylholine alfa, beta
• ?????
• ????????? ?
• ???????? ???? N Norepinephrine
• 
  (Noradrenaline)

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????????? ?? ????????????, ????????? ? ???????
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(No Transcript)
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??????????? ?? ????????????
???????-?-????????????????
6
?????????? ?? ?????????

• F. Stolz 1904

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?????????? ?? ????????? ? ????????????

• ??????????? ???? ??????-???

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Adrenaline / Epinephrine
BP2007 Beta-adrenoceptor agonist used in
treatment of glaucoma.
Adrenaline Tartrate, Ph Eur
(R)-1-(3,4-dihydroxyphenyl)-2-methylaminoethanol
Ph Eur
Noradrenaline / Norepinephrine
Alpha-adrenoceptor agonist
hydrochloride
Tartrate
(R)-2-amino-1-(3,4-dihydroxyphenyl)ethanol
9
??????????????

• ???????????? ??????????
• ???????????
• ???????? (?????????????)
• ?????????????????
• ????????????????
• ?????????????
• ???-??????
• ??????????? ??????.

10
?????? ?????????/?????????
???????? ????????
??? ??-????? ??????-????? ? ????????? ????????

???????? ?? ???????????????????? ????????
???????? ?????????? ????????, ?? ?? ????????
11
?????????????? ?? ??????????????????? ?
?????????????? ?????????

• ????? ?????????, ???????????? , ???????????.
• ??????? ???? ??????? ???????? ???
  ????????????????? ????????????? ?? ?????????????
  ?? ?????? ?? ???????? ????????? ?????????
  ????????? ??????? ?? ?????????????.

12
?????????????? ?? ??????????????????? ?
?????????????? ?????????
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(Ph Eur)

(RS)-1-(3,4-dihydroxyphenyl)-2-(1-
methylethyl)aminoethanol hydrochloride
sulphate
sympathomimetic beta-adrenoceptor agonist
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????? alfa-?????????????????

• ??????? ?????????

?????????????
??????, ?? ????????? ?? ??????????
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Hydrochloride
Tartrate
1-(4-hydroxyphenyl)-2-methylaminoethanol
Adrenergic vasopressor
Antihypotensive
Sulfate
4-2-(Methylamino)propylphenol
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2-(naphthalen-1-ylmethyl)-4,5- dihydro-1H-imidazol
e hydrochloride
nitrate
Ph Eur
Sympathomimetic
Adrenergic (vasoconstrictor)
Alpha-adrenoceptor agonist
Ph Eur
2-4-(1,1-dimethylethyl)-2,6-dimethylbenzyl-4,5-d
ihydro-1H-imidazole hydrochloride.
2-4-(1,1-dimethylethyl)-2,6-dimethylbenzyl-2-imi
dazoline hydrochloride
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????? ???????????????? ? alfa- ? beta-
?????????????????? ????????
Ph Eur
(RS)-2-ethylamino-1-(3-hydroxyphenyl)ethanol
hydrochloride
Antihypotensive
Sympathomimetic
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????? beta- ?????????????????
Orciprenaline

• Beta-????????????????? ???????????? ? beta1 ?
  beta2 ????????

di(RS)-1-(3,5-dihydroxyphenyl)-2- (1-
methylethyl)aminoethanol sulphate
Isoprenaline
Ph Eur
Beta-adrenoceptor agonist
(RS)-1-(3,4-dihydroxyphenyl)-2-(1-
methylethyl)aminoethanol hydrochloride

sulphate
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Beta2-????????????????? ?? ??????? ?? ??????????
?????

• CLENBUTEROL

FENOTEROL
Ph Eur
(1RS)-1-(3,5-dihydoxyphenyl)-2- (1RS)-2-(4-hydro
xyphenyl)- 1-methylethylaminoethanol
hydrobromide
(1RS)-1-(4-Amino-3,5-dichlorophenyl)-2- (1,1-dim
ethylethyl)aminoethanol hydrochloride
Ph Eur
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Ph Eur
Salbutamol
(1RS)-2-(1,1-Dimethylethyl)amino-1- 4-hydroxy-3
-(hydroxymethyl)phenylethanol

Salbutamol Sulphate
Bis(1RS)-2-(1,1-dimethylethyl)amino-1- 4-hydro
xy-3-(hydroxymethyl)phenylethanol sulphate
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Terbutaline Sulphate
Ph Eur
bis(1RS)-1-(3,5-dihydroxyphenyl)-2- (1,1-dimethy
lethyl)aminoethanol sulphate
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TRETOQINOL
(R,S)-1,2,3,4-tetrahydro-1- (3,4,5-trimethoxyphen
yl)methyl- 6,7-isoquinolinediol hydrochloride
Ph Eur

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(1RS)-1-4-Hydroxy-3-(Hydroxymethyl)phenyl-2- 6
-(4-phenylbutoxy)hexylaminoethanol
1-hydroxynaphthalene-2-carboxylate
Ph Eur
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????????????????? ??? ??????? ????????Ephedrine

• ???????? ??????????????? ?? ????????????
• ??????? ?? alfa- ? beta- ???????????

(Ephedrine Hemihydrate, Ph Eur monograph 0489)

bronchodilator
(1R,2S)-2-methylamino-1-phenylpropan-1-ol
hydrochloride
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(No Transcript)
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(No Transcript)
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Mephentermine

• Antihypotensive

Sulfate
2-methylamino-2-methyl-1-phenylpropane
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???????????????(???????????? ???????????,
???????????? ???????)

• ?????????? ? ????????????
• alfa-???????
• beta-???????
• ?lfa1- ? beta-???????
• ???????????? alfa-???????
• ????-????????? (?????? ????? Secale cornutom)
• ?????? ???????, ????? ??? ???????????? ?????.
  ???????-???????????? ???????? ??
  ?lfa-??????????????? ?-? ? ?????????? ?? ??????
  ?????????? ?????.

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Used in treatment of migraine
Ph Eur
mesilate, tartrate
Ph Eur
Ergotamine Tartrate
Used in treatment of migraine
bis(6aR,9R)-N-(2R,5S,10aS,10bS)-5-benzyl- 10b-h
ydroxy-2-methyl-3,6-dioxo-octahydro-8H- oxazolo3,
2-apyrrolo 2,1-cpyrazin-2-yl- 7-methyl-4,6,6a,
7,8,9-hexahydroindolo4,3-fgquinoline-9-carboxami
de tartrate
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Dihydroergocristine Mesilate
Ph Eur
vasodilator
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Antihypertensive
Alpha-adrenoceptor antagonist
(RS)-benzyl(2-chloroethyl)1-methyl-2- phenoxyethyl
amine hydrochloride
N- (2-Chloroethyl)- N- (1-methyl-2-phenoxyethyl)be
nzenemethanamine N- (2-chloro ethyl)- N-
(1-methyl-2-phenoxyethyl)benzylamine BP2007
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4,5-Dihydro-2-(phenylmethyl)-1 H- imidazole
2-benzyl-2-imidazoline
Vasodilator (peripheral)
Hydrochloride
Sulfate
alpha-(butylamino)methyl-4-hydroxy
benzenemethanol
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Antihypertensive
1-(1,4-????????????-6-??)-3-(3-?????-1-???????????
)-1-????????
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(6aR,9R,10aS)-10a-Methoxy-4,7-dimethyl- 4,6,6a,7,
8,9,10,10a-octahydroindolo4,3-fgquinolin- 9-ylm
ethyl 5-bromopyridine-3-carboxylate
Ph Eur
Antihypertensive
Vasodilator (cerebral, peripheral)
(8b)-10-Methoxy-1,6-dimethylergoline-8-methanol
5-bromo-3-pyridinecarboxylate (ester)
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?????????? (alfa1)
PRAZOSIN
?????????????????
1-(4-?????-6,7-?????????-2-???????????)-4- (2-????
???????????)-????????? ???????????
1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4- (fura
n-2- yl-carbonyl)piperazine hydrochloride
Ph Eur
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1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)- 4-(2RS)
-2,3-dihydro-1,4-benzodioxin-2- ylcarbonylpiperaz
ine methanesulphonate
DOXAZOSIN
Ph Eur
Vasodilator
????????????????? 1-(4-?????-6,7-?????????-2-?????
??????)-4- (2,3-???????-????????????-2-??)???????
?-????????? ??????????? (?????????????)
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URAPIDIL
????????????????? 6-3-4-(2-????????????)-1-????
??????????????????- 1,3-???????-2,4-(1?,3?)????
?????????
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TAMSULOSIN 5-2-2-(2-?????????????)???????????
????- 2-??????????????????????? ??????????? ???
??????????? ?? ??????????
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Alpha-and beta-adrenoceptor antagonist
LABETALOL
2-????????-5-1-????????-2-(1-?????-3- ??????????
?)????????????????? ??????????? ???????????????
??
Ph Eur
2-hydroxy-5-1-hydroxy-2-(1-methyl-3-phenylpropyl
) aminoethylbenzamide hydrochloride
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??????????? ????????, ?????????? ???????????????
(????????? ???????) ?? ????????????

• GUANETHIDINE

Ph Eur
Adrenergic neurone blocking agent
1-2-(hexahydroazocin-1(2H)-yl)ethylguanidine
monosulphate
2-(??????????-1(2?)????????)????????????
?????? ?????????????????, ?????????????
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METHYLDOPA
?????????????????
Ph Eur
(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropa
noic acid
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Rauwolfia serpentina L. Benth., Apocynaceae
RESERPINE
?????????????????