Cell Division and Apoptosis III

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Cell Division and Apoptosis III

• Chapter 17

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Activation of a cyclin dependent kinase
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CdK activity can be suppressed by inhibitory
phosphorylation
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CdK activity can be suppressed by inhibitory
proteins
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The Rb protein acts as a brake in mammalian cells
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Programmed Cell Death - Apoptosis
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Digits in developing mouse paw are formed through
apoptosis
cells undergoing apoptosis
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Apoptosis causes tadpole to lose tail
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Necrosis vs. apoptosis
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DVD clip 77
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Caspase cascade occurs during apoptosis
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Procaspase is activated by an active caspase
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4 types of intercellular signaling
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An animal cell depends on extracellular signals
to survive or divide
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An animal cell depends on extracellular signals
to differentiate. Without extracellular signals
the cell will die
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Platelet derived growth factor was the first
mitogen isolated
stimulates cell division during wound healing
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Mitogens stimulate G1-Cdk and G1/S-Cdk activities
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Ras is activated by tyrosine kinase
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p27 suppresses CdK activity
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The Rb protein acts as a brake in mammalian cells
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Excessive stimulation of mitogenic pathways leads
to cell cycle arrest or apoptosis
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Cell growth like cell division is also stimulated
by extracellular signals
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Comparison of nerve cell size vs. lymphocyte size
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Fresh medium stimulates cell growth by adding
mitogens
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Many types of normal animal cells need anchorage
to grow and proliferate
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cell on small patch
cell spread on large patch
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Myostatin inhibits proliferation of skeletal
muscle cells