EULAR 2005

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2005????????????????????
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EULAR 2005

• ????????
• EULAR
• (The European League Against Rheumatism )
• ??????2005 ?6?8?11????????

3
??????????
????? (Spondyloarthropathy)
????? (Spondyloarthritis SpA)
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SpA??????

• NSAIDs???
• ?????DMARDs
• ?????
• ???
• ??????
• TNF???
• ?CD20?????

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• ???
• ???
• ?????
• ?????(??,??,??,??,?????)
• ????

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??SpA???

• ?????
• NSAIDs????AS????????????SpA????????
• DMARDs?SpA??????????????????????,?????????????

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• ????AS????TNF???????AS???????????
• ???????????50??????
• MRI???????, TNF??????????????????????
• ?????TNF????????????????SpA??????????????

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????SpA????????

• TNF???
• Etanercept(??? Enbrel)
• Infliximab (??? Remicade)
• Adalimumab(??? Humira)
• ?CD20?????
• Rituximab (??? Rituxan)

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AS????????

• ?? Braun
• TNF?????AS?????????AU(AS????????)????
• 236/717?(32.9)?AU??
• Infliximab???????,AU????3.4??
• Etanercept???????,AU????6.4??
• ??? 16.2?? (P0.001)
• ????TNF???????AU????,?Infliximab????????

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• ???? EL-shabrawi
• ??Infliximab??????????????????????????(RESCU)
• Infliximab 5mg/kg 49? 10?
• 78 ??????????????????,??????????

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??????Infliximab??AS

• ??????
• 5mg/kg ?6???
• ???? Jois
• 3mg/kg ?8??? 3?
• 13?AS??12?????????????
• ??????????
• ?? ???? 3mg/kg ?8???
• ????????????????

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??????????????

• ??? Joven
• 168?TNF?????????9????????
• ????48.5? ????13?
• 7???????,2?????,1?????
• ???TNF??????????????,????????????????????????

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??!