Change From Baseline to Endpoint in BP and HR

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Change From Baseline to Endpoint in BP and HR
Least Squares Mean (Standard Error) Least Squares Mean (Standard Error) Least Squares Mean (Standard Error)
SBP (mmHg) DBP (mmHg) HR (bpm)
History of Hypertension History of Hypertension History of Hypertension History of Hypertension
Placebo (n459) -2.4 (0.64) -1.0 (0.39) -0.7 (0.44)
Tapentadol ER (n462) -2.7 (0.64) -1.3 (0.39) 0.2 (0.43)
Oxycodone HCl CR (n413) -3.7 (0.67) -2.3 (0.41) -0.9 (0.45)
Concomitant Antihypertensive Medication Concomitant Antihypertensive Medication Concomitant Antihypertensive Medication Concomitant Antihypertensive Medication
Placebo (n429) -1.8 (0.66) -0.7 (0.40) -0.6 (0.45)
Tapentadol ER (n434) -3.3 (0.65) -1.4 (0.40) 0.1 (0.44)
Oxycodone HCl CR (n387) -3.7 (0.69) -2.3 (0.42) -0.7 (0.47)