Mean Responses on PGI-Improvement Primary Endpoint at Week 12

1
Mean Responses on PGI-Improvement Primary
Endpoint at Week 12
Very much better 1
Much better 2




A little better 3
No change 4
2
4
8
12
A little worse 5
Week of Study
Much worse 6
Very much worse 7
Plt0.001 vs placebo
PGIPatient Global Impression.
At week 12 57 of duloxetine patients who had a
PGI-I score 2, which was significantly more than
patients in the placebo group.
2
LOCF Mean Change from Baseline to Endpoint in MFI
Subscale Scores
Baseline
Improvement





General Fatigue
Physical Fatigue
Mental Fatigue
Reduced Activity
Reduced Motivation
P 0.05 P 0.01 P 0.001
LOCF last observation carried forward MFI
Multidimensional Fatigue Inventory.
There were no significant between-treatment
differences at baseline.
3
LOCF Mean Change from Baseline to Endpointin
Beck Depression and Anxiety Inventories
Plt0.01 vs placebo
LOCF last observation carried forward.