?????????? ????????, ??

1
??????????? ?? ????????????? ???????

• ????????? ????????
• ??????? ?? III ???? ????????
• ?????????? ????????, ?? ?????
• (2011)

2
????????????

• ??????? ?????????????? ??????? ??? ???????? ???
  ? ??????? ?????????, ????? ?? ?? ???????? ?
  ??????? ? ???- ??????????????????

3
(No Transcript)
4
?????????

• ??? ??????????
• ????????? ???????????
• ??? ?????????????

5
(No Transcript)
6
?????????????

• ????????????? ??????
• ??????????? ?? ????????? ? ???????????? ??????
• ?????????????? ??????? ?? ????????????? ??? ????

7
??????????? ?????????
8
?????????? ?? ??? ??????????????????

• ??????????? ???????, ????? ?? ????????????? ?
  ???????-?????????-???????????? ? ?? ???????? ?
  ??? ?? ??????? ?? ???????? ?? ????? ??
  ????????????
• ?? ?????? ?????? ??? ???????????????? ? ??
  ???????????

9
???????? ????????? ?? FDA ??

• Azacitidine (Vidaza) 2004?.
• Decitabine (Dacogen) 2006?.

10
Azacitidine

• ????????????????? ???????
• ??????? ?????????- 4 ????
• ????????, ????????????
• ?????? ?????????
• ???????????? ?????
• ?????? ?????? ?? 7 ??? ? ?????? ?? ??????? 4
  ???????
• ??? ?????? ? ?????????
• ?????? ? ???????????

11
Decitabine

• ????????????????? ???????
• ??????? ?????????- 30 ??????
• ????????????
• ?????? ?????????
• ???????????? ?????
• ??????? ??????? ? ??????????????? 3 ????, ? 8
  ????? ???????? ????? ??????????, ? ??????????? ??
  3 ???
• ?????? ?? ???????- 6 ???????

12
?????????? ?? ?????? ?????????????

• ?????????????? ?????????? ????????????, ????
  ????????? ?? ?????? ?????? ???????????,
  ??????????? ????? ????????? ?????????? ?????????
  ?? ?????????, ????? ???? ?? ????????? ?? ????.

13
???????? ????????? ?? FDA ??

• Vorinostat (Zolinza) 2006
• Romidepsin (Istodax) 2009

14
Vorinostat

• ????? ?- ???????? ??????
• ??????? ?????????- 2 ???? ???- 71
• ?????????
• ?????? ?????????
• ???????????? ?????
• ?????? ?????? ?? ????? ?? ???????
• ?? ?? ?????? ???? 2 ? ???? ??????
• ???!

15
Romidepsin

• ????? ?- ???????? ??????
• ??????? ?????????- 3 ???? ???- 94
• ????????????
• ???????????? ?????
• ???????????? ??????? ?? 4 ???? ?? ????? 7-??
  ??? ? ??????????? ?? 3 ???????. ???? ????? ??
  ??????? ???? ?? ?? ??????? 28 ??? ???? ???????
  ????

16
??????????? ???????

• ???????????? ?????? ???? ?????????? ?? ??????
  ?????????????
• ???????????? ???????, ?????????? ??
  ?????????????? ????????????, ???????????? ???
  ???????????

17

• ?????? ???? ????????? ???????? ?????? ???????????
  ??? ???????????? ???????????. ??? ?? ?? ????
  ????????? ?? ????, ? ???? ????????? ?????? ??
  ???????? ???? ?????.
• ?????????????? ?? ? ?????????????? ?? ??????????
  ?? ? ????? ?? ???????? ???????? ??????? ??
  ????????? ?? ??????? ????????? ? ???? ? ????????
  ?? ?????????? ??????? ?? ??????

18
??????

• ???????????? ?? ????????? ????? ? ??????????
  ??????
• ???????????? ?? ????????????? ??????????? ?????
  ?????????? ???? ? ???????? ??????

19
????????? ?? ??????????!
20
?????????? ??????????

• ?????????? ???????? ? ????????????? ???
• ?? ????. ????? ??????? 2010?.
• Epigenetics in Cancer What's the Future?
• By Yanis Boumber, MD, PhD, Jean-Pierre J. Issa,
  MD
• Epigenetics in Cancer The new england journal of
  medicine
• Manel Esteller, M.D., Ph.D.
• Epigenetic therapy - a new development in
  pharmacology
• Jacob Peedicayil
• Anti-Cancer Agents in Medicinal Chemistry, 2009,
  9 Radiosensitizing Potential of Epigenetic
  Anticancer Drugs
• By Harlinde De Schutter and Sandra Nuyts
• Cancer Epigenetics and Targeted Therapies
• By Benjamin Tycko, MD, PhD
• Epigenetic Targeted Anti-Cancer Drugs An
  Unfolding Story
• By Paul A. Marks, MD
• Epigenetic tools in potential anticancer therapy
• By Sebova, Katarina Fridrichova, Ivana
• Combining Epigenetic and Cytotoxic Therapy in the
  Treatment of Solid Tumors
• By Elizabeth R. Plimack, David J. Stewart,
  Jean-Pierre J. Issa