????

1
?????????????????????????????????
????????

• ???? GREI?????
• ?????? ???????????
• ??????????
• ??17?5?11?(?)

2
???????????????????????
?????????

• ??
• ?????????1???????????(????)
• ??????????????????????(????)
• ??...

RIKEN Ring Cyclotron
135 MeV / nucleon
12C, 14N, 16O
???? Ag, Au
??
??
??
?
Mn
Co
??????? ????????? ?????????? 1991????211?
(2004.04??)
????
V
Zn
??????????
Sr
Se
Eu
Cs
Ge
Fe
?????????
Rb
????
???????????????????????????????????????????
??????????????????????? ?????????????????????????
?????
3
Zn(??)??????????
????????????? ? PET?????FDG??????????
????????
??????????????????????????
A. Takeda et al., CANCER RESEARCH 61, 5065 (2001).
4
?????????????(GREI)??
GREI ???????
GREI ??????
?????????? Ge ???

• ???????????????????????
• Eg E1 E2 ? ?????
• E1, E2 ??????????? ? ???????????? ?????????
• ????????????? ? ????????

• Ge ????? Front 39mm x 39mm x 10mmRear 39mm x
  39mm x 20mm
• ?????????? 3 mm (13 strips on each side)
• Ge ?????? 60 mm

5
?????????

• 2????????

Step 1
Step 2
?????
???????
?????(SBP)??

• ??? (1116 keV) ?SBP??

10 events
105 events
SBP???????????????????????????????
SBP??
??????
????(PSF)
6
?????????
?????????????????????
?????????? ??????? ??? ?????
??? ????????
?
?
??????? ?????????????
??????????????????? ????
SBP??
??????
????(PSF)
7
????SBP???????????????
Counts
Counts
8
??????????????????

• 137Cs, 59Fe ??? 65Zn ????????????

??(??)
137Cs 59Fe 65Zn
GREI ??????????????
137Cs 630 kBq 59Fe 140 kBq 65Zn 50 kBq
GREI ???????RI ????
9
????????????????? 3D ?????

• GREI ???????????????3D ????????????

Top view
137Cs, 59Fe ??? 65Zn ????????
Side view
Front view
3D ?????? (137Cs)
10
??????????????????

• 65Zn, 59Fe ??? 88Y??????????????

Control
65Zn 59Fe 88Y 6??
??
GREI ??????????????
Tumor
????????
65Zn 60 kBq 59Fe 30 kBq 88Y 10 kBq
C57BL mouse
GREI ???????RI ????
11
????????????????? 3D ?????
Control
Tumor
C57BL mouse
PSF
????????
????PSF(z 15 mm) ????????
SBP??(59Fe, ???)
????????
????PSF(z 30 mm) ????????
12
????PSF????
t, t ????? ? ????????????????
???? PSF ???????????????
???????????

• ????? ???CT ???? SIRT ??????????
• ??????? ???????????? n ??????????n1
  ?????????????? ? SBP ??? ????? PSF
• ???? PSF ??????????????????????? PSF ????????????

13
??????? 2D ????????
Fig. 1. Reconstructed images of 59Fe administered
to a soybean sample. (a),(b) Using the
analytical algorithm. (c),(d) Using the
iterative algorithm.
14
??????? 3D ????????
Tumor
Liver
?????????? 65Zn ?????
15
???

• GREI ??????????????????????
• ??
• SBP???????????????????
• PSF?????????????????????? z????????????3D????????
  ?
• PSF????????????????????????????
  ????PSF????????????? z????????????3D??????
• ????

• ????PSF???
• ???????
• ????????
• SBP??????????????
• ?????????????????