???????

1
??????????
?????? ??? ???
2
?????????????????
3
????????????????

• 1.??????????????????????

?????
UFLP???
????
??????????????????TAE?????VEGF??????,???????
4
2. ???????????????????????????VX2??????TACE
???????????????
N15 tAI0.711,Pgt0.05 tPI5.31,Plt0.01 tSPF2.96,Plt
0.05
AI???? PI???? SPFS?????
5

• ?????????????????,??????????????
• TACE???????????????????????,?????????????????,????
  ????????????

6
???????????

• ???(lipiodol)
• ??????(microsspheres)???(microcapsules)
• ???(liposomes)
• ???(nanoparticles)
• ????(magneticmicrosperes)
• ????(multiple emulsion)???(microemulsion)?????(cel
  lular carriers)
• ?????(immune nanoparticles)?????? (immune
  liposomes)

7

• ????????(drug-macromolecular conjugates)
• ??-?????(drug-ligands conjugates)
• ??-????????(drug-monoclonal antibody
  conjugates)???DDS(drug deliver systems,DDS)?????,?
  ?DDS??????????????????????????????????????????????
  ???????????????(??)???????????????

8
?.?????????

• Konno T?????330??????????????110??????????????????
  ????????????330??????1?2?5????????85?52?34,110
  ?????1?2?5????????61?32?22?

9

• ??????????5-FU?????????????????,????????????
• ?????5-FU?????11??????????????????,
  5-FU??????????????,?????(AUC)???????(Vc)????,?????
  (T1/2a)??????(T1/2ß)????,???????3.7??9.38?(Plt0.01)
  ,??????

10

• ???????????????????????????????1-100nm.???????,???
  ??????????????????????,?????????????????????,????
  ????????(RES)???

11

• ???????????????(5-FU ELSE)???????????????????,?70
  ???????
• ???????????a-????????????(NADM)???????????,???????
  ??????????????????????????????????????????,??24???
  ???????????80??,????????????????????

12

• Soma?????,???????????????????????,??kupffer???????
  ??,??????????,????????????????????????,???????????
  ??????,???????????

13
?.?????????

• ?????????????????,?????????,???????????????(?)????
  ?????
• ????????,????????????????????????????????,????????
  ?????,???????????????????,???????

14
?.?????????

• ??????????????,????????????????????????????,?????
  ???????????????????????,????????????????,?????????
  ??????????
• ??????????????????????,???????????,???????????????
  ?????,???????????

15

• ????????????????????????
• ????
• ????????
• ?????????
• ??????????

16
?????????(EGFR)

• ?????????(EGFR)??????????????????????????EGFR?????
  ??,?????????????????????
• EGFR?????????(EGF)?????????????,?????????,????????
  ??????,???????????

17
?????????(EGFR)

• ????,?????EGFR????,???????????????????EGFR????????
  ???????,?????????????,
• ????(Gefitinib Iressa)????EGFR????????,??????EGFR?
  ???????????????,??????????????????,???????????-9??
  ?,???????????

18
????????????(VEGFR)

• ??????????????????????????????????????????????????
  ????,??????????????????????????(VEGFR),???????????
  ?????????????????,????,????????????(VEGF)????,????
  ???????????

19
????????????(VEGFR)

• ????????????????,TNP-740??????????????????BB
  -94(batimastat)????????????????????VEGF?VEGFR?????
  ??????????????Bevacizumab(Avastin)????????????VEGF
  R?????????,???????????

20
?????

• ?????(??)???????????????,???????????????????????MA
  b????????(AFP)??,?????????????HIII?HAb18?HAb25?,??
  ??????????????(131I?125I)?????(??????????????)????
  ?????

21
?????

• Al-Iufti RA??????131I-????????????????????????
  131I-?????????????????????,???????????????

22
?????

• ???????????????????????????,???????????????131I?
  ?????????,???131I??ß???????????,??????????????
  ????????

??6?ECT
???? 2008 ???
23
????

• ?????????????????????????????????????????????????
  ???????????????,????????????

????

• ????????????
• ?????????????
• ??????????

24
????
????????????? ??????(??????-2??????12?a2????ß2??
????????a),?????????????(?p53???)???????(HS-tK?)??
?????????????RNA?????
25
????

• ????????????(??????????)?????????Gerolami???,?????
  ??????1(HIV-1)????????????????????HCC??,??????????
  ,?????????????????

26
??????????

• P53 ?????????,????????????????,
  ???????DNA????, P53?????DNA???????????,
  P53???????????,??????,???????????????????P53
  ???????????????????

27
??????????

• ?????????????p53???????????,????????14d,??405d,??2
  38.1d?????????18d,??167d,??80.7d(plt0.01),???p53???
  ????????

??????P53??
P53??????(???? 2006)
28
??????????

• ????????????????????????????????,??????????
  ?????,??????????????????????????????RNA???DNA?????
  

29
??????VEGF?????????
1d
3d
6d
? ? ?
Liver
TAI ?
Liver
???? 2004
30
?????????

• ???????????TNF-a?????????????,
  ????????TNF-a??????

Ki67??
rmhTNF??TACE???MVD?ki67???(????,2004)
31
????????
?????????????????,???????????,?????????????
?,???????????????????????????,????????
32
???? RNA???????
RNA??????RNA???mRNA ?????????????,?????????????
,????????????????????????????RNA
???????????????????,???????????????
33
??????????
?????????????????????????,????????,?????
??????????????????????????????,??????????????????

• Lin?????????????(MEL)???AFP?????,?????????????????
  ???????

34
????????? ????

• ???????????
• ???????

35
???????????????

• ????????????????,????????????
• ?TACE?????????,?????????????,??????????????,????
  ????????????
• ???TACE?????????????????????,???????????

36

• ?. ????????????21??????????????,????????????,????
  ??????????????,?????????????,????????????,????????
  ?????????????????????,?????????,?????????????,????
  ??????????????????,?????????

37

• ??, ?????????????????????,?????????????????,??????
  ???????????????????????,?????????????????????????,
  ?????????????????????,?????????????????????