--------T G G ------ --------T G T ------

1
Most of us Jeremy
Coding DNA
--------T G G ------ --------T
G T ------
Template DNA
--------A C C ------ --------A
C A ------
Messenger RNA
--------U G G ------ --------U
G U ------
Amino Acid
--------TRYPTOPHAN ------
--------CYSTEINE ------
These guys also carry mutationsapparently
2
--------T G T ------
-----T G G ----
With point mutation G to Tie a substitution
X Man Jeremy
Most of us
ISO
ISO
The offending amino acid
LEU
LEU
ALA
ALA
CYS
TRY
ASP
ASP
ISO
ISO
PRO
PRO
Blimmin X Men everywhere
3
What would be the result if the mutation was a
substitution of the G to a C ?
-----T G G -----
Most of us
ISO
ISO
Dont forget to go coding DNA template
DNAmRNAA A
LEU
LEU
ALA
ALA
?
TRY
?
ASP
?
ISO
?
PRO
4
Original
With MUTATION
TGG
TGC
Coding DNA
Template DNA
ACG
ACC
mRNA
UGG
UGC
Cys
Try
Amino Acid
What theThat is the same as Jeremy How come?
There are 64 codons and 20 amino acids, thats
how come
5
The answer...
X Man Jeremy
Most of us
ISO
ISO
LEU
LEU
ALA
ALA
CYS
TRY
ASP
ASP
ISO
ISO
PRO
PRO
So no change then !!!
-----T G c ------ will still give CYS
6
What would be the result if the mutation was a
substitution of the G to an A ?
-----T G G ------
Most of us
ISO
ISO
LEU
LEU
ALA
ALA
?
TRY
?
ASP
?
ISO
?
PRO
7
The answer...
Most of us
ISO
ISO
LEU
LEU
ALA
ALA
STOP!
TRY
ASP
A non-sense mutation.It will make a very short
proteinMost likely with no function
ISO
PRO