Tissues and Organs Comprising the Immune Response System

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Tissues and OrgansComprising the ImmuneResponse
System
Where components of the immune
response originate, differentiate, meet,
interact, and function
Folder Title TissOrg

• Updated October 30, 2013

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APC and T-Cells
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Marcophage and T-Cell Kissing
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Macrophage to T-Cell Interaction
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Helper T-cell B-Cell Interaction
CD4 co-receptor
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B-Cell Activation
See figure 2-7, Kuby, 4th Ed., p. 36
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B-Cell Small, Blast, and Plasma
See Figure 2-7, Kuby 4th Ed. p. 36
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Where do these cells originate? Where do they go
to interact with each other? Where do they carry
out their functions?
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Primary and Secondary Lymphoid
Related to Figure 2-13, Kuby, 4th Edition, p. 47
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(No Transcript)
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Animations Produced for Kuby Immunology http//bc
s.whfreeman.com/immunology6e/ Chapter 2
Animation. Cells and Organs
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Please put away all notes and any devices except
for your Turning Point NXT Transmitter. No
papers or computers on your desk please. No
communication between or among students.
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Exactly what kind of Cell is the one attached to
the B-Cell? (exactly means not just its general
type of cell, but specifically what it is based
on what this figure shows.)
Rank Responses
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2
3
4
5
6 Other


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What is the blue thing that looks like an
alligator clip on the cell attached to the
macrophage or to the B-cell?
Rank Responses
1
2
3
4
5
6 Other


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What is the purple thing that looks like a hook
on the cell attached to the macrophage or to the
B-cell?
Rank Responses
1
2
3
4
5
6 Other


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Thymus Photo
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Thymus Cartoon
Diagrammatic Cross Section of Thymus. Figure
2-14, Kuby, 4th
Edition, p. 48
ThymusCross
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CD4 and CD8 in Thymus
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MALT and M-Cells
See Figure 2-22, Kuby 4th Ed. p. 56
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(No Transcript)
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(No Transcript)
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MALT and IgA
See Figure 2-22 Kuby, 4th Ed. p. 56
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CD Antigen Table
CDMarks
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CD Antigens Color Coded
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Animations Produced for Kuby Immunology http//bc
s.whfreeman.com/immunology6e/ Chapter 11
Animation. Signal Transduction
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CD Antigen List Pages A1 to A26 339
Entries, 2007 Edition of Kuby
How to Understand CD Antigens 5 Persons in a
Room Person 1 5 ft 5, 160 lbs bespectacled
old geezer Person 2 5 ft 11, 280 lbs, 22-year
old guy, all muscle Person 3 5 ft 5, 135
lbs, 20-year-old woman Person 4 7 ft 1 , 200
lbs, 22 year-old guy Person 5 5 ft 8, 150
lbs, 22 year-old guy
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This is a fill-in-the-blank question. Please
enter your responses as a series of numbers from
1 to 5. Which PersonA. Is a varsity
basketball player?B. Plays on the womens
field-hockey team?C. Is a boring old
professor?D. Is a varsity football player for
SU?E. Is a cross-country runner?__ __ __ __
__
Person 1 5 ft 5, 160 lbs bespectacled old
geezer Person 2 5 ft 11, 280 lbs, 22-year old
guy, all muscle Person 3 5 ft 5, 135 lbs,
20-year-old woman Person 4 7 ft 1 , 200 lbs,
22 year-old guy Person 5 5 ft 8, 150 lbs, 22
year-old guy
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Secrets of Signaling 1. How Do You Knock on a
Door? 2. Why does the phone ring more than
once? 3. Why does the police officer blow his
whistle only once? 4. Why does your computer say
Are You Sure You Want to Delete File XYZ? 5.
When Ashley Nieves asked the class to raise their
right hand, why did only eleven persons out of
95 respond? 6. Why did a different set of
students respond to the same message when InSu Jo
made the request?
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Signal, Receptors, and co-receptor Pairs
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Costimulatory signals B7 CD28
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Costimulatory Signals T-Cell to MPh
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Cancer Eluding Costimulatory Signal
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CDs on B, T, and NK Cells
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T-Cell ALL Markers
(ALL Acute Lymphocytic Leukemia)
Kuby, 5th Edition p. 157
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Pre-B-Cell ALL Markers
(ALL Acute Lymphocytic Leukemia)
Kuby, 5th Edition p. 157
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B-Cell CLL Markers
(CLL Chronic Lymphocytic Leukemia)
Kuby, 5th Edition p. 157
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Leukocyte Recirculation
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Lymphocyte Recirculation
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(No Transcript)
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Leucocytes in Capillaries Cartoon
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Leucocytes in Capillaries Photo
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Extravasation of Naïve T-Cell into Lymph Node
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Adhesion Leucocytes to Endothelium
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(Non-inflamed Endothelium)
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(Inflamed Endothelium)
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CAM Cell Adhesion Molecules
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Membrane of CirculatingLeucocytes
General Structures of Cell Adhesion
Molecules (CAMs) Kuby, 3rd Edition
Figure 15-2a
CAMStruct
Endothelial Cells Lining Capillaries
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Actin Cytoskeleton Linkage to Collagen
Extra-cellular Matrix
Figure 19-14 ECB 1998, p. 603
Collagen
Fibronectin
Integrin
Plasma Membrane
Actin Microfilament
MFtoECM
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CAMinCap Adhesion in Capilaries
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Animations Produced for Kuby Immunology http//bc
s.whfreeman.com/immunology6e/ Chapter 13
Animation. Leukocyte Extravasation
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When a leukocyte traveling in the blood-stream
enter the capillary circulation in a tissue that
is under bacterial attack, which of the following
happen? The system should accept four correct
answers

1. The leucocyte immediately degranulates
2. The leukocyte goes into cell division
3. The leukocycte binds to the capillary endothelial
   cells (High endothelial venules)
4. The leukocyte rolls along the endothelial lining.
5. The leukocyte elicits membrane signals from the
   endothelial cells that bind the leukocyte
   tightly.
6. The endothelial cells then enter apoptosis
7. The leukocyte extravastates
8. The leukocyte makes antibodies

Response Counter
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On a scale from 2 to 2(Use 1 on Key-pad)
-2 Im lost (Use 2 on Key-pad) -1 Im
having a hard time, but I follow some of it.(Use
3 on Key-pad) 0 Im doing OK. I uderstand most
of it. I can figure the rest out later.(Use 4
on Key-pad) 1 Im following OK. No
problem(Use 5 on Key-Pad) 2 This is pretty
straight-forward, Please move on.
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If a red blood cell is an erythrocyte, what is a
T-cell?_________________ cyte
Rank Responses
1
2
3
4
5
6 Other


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Which of the following are Primary Lymphoid
Organs?(Two responses should be accepted by the
system)

1. Mucosal associated lymphoid tissue (MALT)
2. Tonsils
3. Adenoids
4. Thymus
5. Thyroid
6. Bone marrow
7. Cervical lymph nodes
8. Spleen
9. Lumbar lymph nodes

Response Counter
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T-Cells are lymphocytes that are educated in
the

1. Tonsils
2. Toe-nails
3. Teeth
4. Thyroid
5. Thymus
6. Testicles
7. Thoracic Duct
8. None of the above

Response Counter
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(No Transcript)
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CAMFamly
On Leucocytes
On Endothelial Cells
On Endothelial Cells
On Neutrophils
On Mucosal Epithelium
On Leucocytes
On Endothelial Cells
Families of Cell Adhesion Molecules Kuby, 3rd
Ed. Figure 15-2b
CamFamly
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On a scale from 2 to 2(Use 1 on Key-pad)
-2 Im lost (Use 2 on Key-pad) -1 Im
having a hard time, but I follow some of it.(Use
3 on Key-pad) 0 Im doing OK. I uderstand most
of it. I can figure the rest out later.(Use 4
on Key-pad) 1 Im following OK. No
problem(Use 5 on Key-Pad) 2 This is pretty
straight-forward, Please move on.
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How Well Are You Following What is Being
Presented so Far in theCourse?(This will be set
to anonymous so you will not be identified and
your response will not be graded)

1. Im totally lost.
2. Im having hard time, but I follow some of it.
3. Im OK. I can figure most of it out later.
4. Im following very well. There is no problem with
   the level of the course.
5. This isnt pitched at a level appropriate for an
   upper division undergraduate course. Please move
   to a higher level of challenge.

Response Counter
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Animations Produced for Kuby Immunology http//bc
s.whfreeman.com/immunology6e/ Or search Kuby
Immunology, Click on Kuby Immunology 6e , go
to Student Resources Chapter 2 Cells Cell
Death (Also chapter 10) Chapter 11 Signal
Transduction Chapter 13 Leucocyte Extravasation