Wilson

1
Wilsons Disease

• Yurani Farfan
• Mr. Trefz
• Genetics

2
Wilsons Disease?

• Wilsons disease is a genetic disorder in which
  the body is receiving extra copper in the body
  tissues. The body receives copper from certain
  foods like mushrooms, turnip greens, spinach,
  eggplant, cashews, summer squash and most other
  with enriched vitamins. In Wilson disease, copper
  builds up in the liver, brain, eyes, and other
  organs. Too much of high level copper can cause
  life-threatening organ damages and poisoning in
  the body tissues.

3
What does Copper do to the body?

• Copper plays a big part in our metabolism and
  also maintains the functions in the enzymes in
  our bodies. Copper has another job in bone
  development, tissue reconnection, hair and skin
  development. The average human needs about 75-100
  milligrams of copper in their diet. Basically
  the size of penny.

4
Who can get Wilson Disease?

• Wilsons disease is a rare and common disease
  found in humans. People who have Wilsons disease
  inherit two copies of a ATP7B gene that are
  abnormal from the parent gene. About 1 to 40,000
  people have Wilsons Disease. It affects men and
  women. The start of Wilsons Disease is around
  the ages 5 to 35. But other studies showed that
  it can happen at the age of 2 and 72.

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Symptoms Of Wilsons Disease

• Symptoms of this disease are
• Swelling of the Spleen
• Yellowing in the skin and whites in the eyes.
• Fluid build up in the legs and lower abdomen
• You can bruise easily
• Get tired really easily
• Muscle stiffness
• Problems with speaking, swallowing and
  coordination
• Low level of white blood cell count
• High level of amino acids, protein, uric acids.
• Mood swings

6
Exams Tests

• When having a test for Wilsons disease, doctors
  will check for
• Yellow in iris
• Limited movement in the eyes
• Physical examination of central nervous system,
  coordination, loss of thinking, stiffness in
  muscles, and memory loss.
• Liver or spleen disorders
• Lab test will also look into white blood cell
  count, copper, and uric acid.
• Problems in the liver will be tested for High AST
  ALT , high bilirbin , PT and PTT
• And Low Albumin

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Diagnosis
8
Treatment

• Wilsons Disease is a life long disease. Therapy
  will have to be in place. The therapy removes
  excess copper in the body before any poising in
  the body occurs. Medication is provided for
  Wilsons disease. Women who are pregnant should
  take a less amount of the medication. The
  medication is d-penicillamine (Cuprimine) and
  trientine hydrochloride (Syprine). These both
  drugs release the cooper in the organs so they
  dont build up.

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What to avoid!

• People who have Wilsons disease are on a strict
  diet. They cannot have a large amount of copper.
  They should avoid Chocolate, Shellfish, dried
  fruit, Mushrooms, and Nuts. When drinking water
  people with this disease must have their water
  checked out just in case it has copper.

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Biliography

• http//www.whfoods.com/genpage.php?tnamenutrient
  dbid53
• http//digestive.niddk.nih.gov/ddiseases/pubs/wils
  on/what
• https//health.google.com/health/ref/Wilson'sdise
  ase
• http//health.nytimes.com/health/guides/disease/wi
  lsons-disease/overview.html
• "ATP7B." Encyclopædia Britannica. 2009.
  Encyclopædia Britannica Online. 11 Nov. 2009
  lthttp//www.britannica.com/EBchecked/topic/1525291
  /ATP7Bgt.