SPINTRONIC NANOSENSORS for MEDICINE

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SPINTRONIC NANOSENSORS for MEDICINE Prof.
Riccardo Bertacco Centro LNESS Politecnico di
Milano Via Anzani 42, 22100 Como riccardo.bertacco
_at_polimi.it
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Spintronic biosensors for molecular recognition
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streptavidin
probe
biotin
target
Advantages

• No background
• No bleaching
• High stability
• Molecule handling
• High biological sensitivity
• Tayloring the dinamic range
• Lab on chip

Disadvantages

• Not label free
• Impact of beads on the chemical affinity ?

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SpinNanoMed FP7 NMP-2008-1.1-1 Converging
sciences and technologies (nano, bio, info and/or
cognitive)
SPINTRONIC NANOSORS for MEDICINE

• Preventive medicine and diagnosis (in vitro
  diagnostic tests)
• Specific application
• Early detection of breast cancer via proteome
  profiling on the serum of patients

Lab on chip approach for point of care
applications.
End users Antibody Microarrays C. Borrabaeck, Create (Sweden)
User Interface, Data correlation and knowledge discovery Database and Web Group Bioinformatics Lab P. Fraternali, S. Ceri, M. Masseroli Politecnico di Milano (Italy)
Signal de-noising and data analysis Digital Signal Processing Group- ISP Lab M. Tagliasacchi Politecnico di Milano (Italy)
Signal read-out and LabOnChip electronics
Microfluidic transport Institut fur Mikrotechnok Mainz GmbH K. S. Drese (Germany)
Surface functionalization ICRM M. Chiari CNR (Italy)
Microfabrication of lab on chip micro arrays of spintronic biosensors Spintronic group at LNESS nanoGune MIC - Copenhagen R. Bertacco Politecnico di Milano (Italy) A. Berger, P. Vavassori (Spain) M. F. Hansen (Denmark)
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System layout
Biomedical validation
DSP Data mining End user interface
AD conversion
Microfluidics
SiO2 polymer
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Electronics

• An ASIC, to be placed around the sensor chip,
  must be designed and realized with these
  functionalities
• front end electronics for the signal read out
• analogical signal processing (filtering,
  amplification, ...)
• A second external circuit will make the analog to
  digital conversion and provide suitable signal to
  an external PC for data acquisition and analysis.