ISGO: The International Structural Genomics Organization

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ISGO The International Structural Genomics
Organization

• Goals of ISGO
• Develop standards and policies for structural
  genomics
• Sponsor international meetings and workshops
• Promote cooperation in structural genomics,
  including between public and private efforts
• Promote deposition of coordinates, raw data, and
  other information

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ISGO 2000-2001Led by John Moult, Chris Sander,
John Norvell, Barbara Skene

• Workshops on international cooperation
• Hinxton (April, 2000) and Airlie House (April,
  2001)
• Task Forces
• Task Force on Deposition, Archiving, and Curation
  of the Primary  Information (Helen Berman and
  Geoff Barton, chairs)
• Task Force on Mechanisms for Publication and
  Recording of Methods  and Results (Guy Dodson,
  chair)
• Task force on Intellectual Property (John
  Norvell, Barbara Skene, chairs)
• Task Force on Numerical Criteria in Structural
  Genomics (Randy Read, chair)
• Task Force on Target Tracking (Steve Bryant,
  chair)
• Workshops on in vitro expression systems
  (Shigeyuki Yokoyama)

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ISGO 2000-2001 Agreed Principles and Procedures

• Coordination of International Programs in
  Structural Genomics
• The goal is to encourage harmonious cooperation
  among a broad range of public and private sector
  institutions in the international effort to
  characterize macromolecular structures in living
  organisms on a pan-genomic scale
• Key Principles
• Free exchange of data and materials
• Deposition of coordinates and other mandatory
  data in the PDB immediately on completion of
  structure determination
• Public release in a short time (always less than
  6 months)
• Open exchange of target information

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ISGO 2000-2001 Additional recommendations

• Short peer-reviewed papers to ensure quality
  (Proteins, Structure Function and Genetics Acta
  Cryst. D in place now)
• Quality is not to be sacrificed in the interests
  of quantity
• Structure depositions will be accompanied by
  experimental data
• Access to material such as clones, cell lines,
  and protein samples encouraged
• Exchange of protocols and materials encouraged
  (Clearinghouse recommended)
• Promote the free access and exchange of
  scientific information among scientists engaged
  in basic research.
• Harmonize patent law.
• Strengthen the utility requirement for
  patentability. (Community is concerned about the
  implications of the granting of patents based
  solely on the submission of three-dimensional
  structural co-ordinates, without any identified
  non-trivial utility.)

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ISGO Today

• Open membership
• news_at_isgo.org mailing list
• Web site
• http//www.isgo.org
• An executive committee
• Continuing members Shigeyuki Yokoyama, Udo
  Heinemann, Tom Terwilliger
• New members Seiki Kuramitsu, Ian Wilson, David
  Stuart
• An Advisory Board
• Gaetano Montelione , Guy Dodson, Chris Sander,
  Dino Moras, Joel Sussman, Wayne Hendrickson,
  John Norvell, Barbara Skene, Norihisa Hara
• Active Task forces
• Task Force on Deposition, Archiving, and Curation
  of the Primary  Information (Helen Berman,
  chair)
• Task Force on Mechanisms for Publication and
  Recording of Methods  and Results (Guy Dodson,
  chair)
• Task force on Intellectual Property (John
  Norvell, Barbara Skene, chairs)

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ISGO and the Structural Genomics Community

• Sponsored International Conference on Structural
  Genomics in Berlin, Oct 10-13, 2002 (Udo
  Heinemann, organizer)
• Sponsored workshops for collaborative efforts and
  sharing of technology
• in vitro expression workshops (2001-2002,
  Shigeyuki Yokoyama)
• Collaboration in high-throughput crystallography
  (March 2002, Tom Terwilliger)
• Automation of X-ray Structure Determination of
  Macromolecules (Oct, 2002, Uwe Mueller)
• Run pre-conference ISGO session on structural
  genomics policies (Oct, 2002)
• Sponsoring next International Conference on
  Structural Genomics (USA, 2004/2005   (Gaetano
  Montelione Tom Terwilliger have volunteered to
  organize)

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Suggested ISGO statement on patentability of
protein structures

• ISGO strongly supports the position that a high
  level of utility should be required for patenting
  of protein structures
• NOTE ISGO continues to expect that most
  structures will be
• immediately deposited and released, as agreed at
  Airlie House.

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Continued work of Task Forces
Task Force on Deposition, Archiving, and
Curation of the Primary Information. (Helen
Berman, chair) Development of data dictionary for
deposition of all relevant experimental data
(cloning, protein production, crystallography,
NMR) Development of target tracking web site and
structural genomics pipeline for deposition to
PDB Task Force on Mechanisms for Publication and
Recording of Methods and Results (Guy Dodson,
chair) Negotiate with journals to create a smooth
pathway for publishing short structure
reports (Identify what should be in short
articles) Task force on Intellectual Property
(John Norvell and Barbara Skene) Discussion and
drafting of proposed policies on patenting and
structural genomics