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Computational Modeling of H5N1 Hemagluttinin

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Construct a valid computational model of H5N1 avian flu ... Most vacation spots in China are tacky and polluted (although often with breathtaking vistas) ... – PowerPoint PPT presentation

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Title: Computational Modeling of H5N1 Hemagluttinin


1
Computational Modeling of H5N1 Hemagluttinin
  • Chinese Academy of Sciences, Beijing
  • ??? (Ryan Ferrell)July 23, 2007

2
Project Goals
  • Construct a valid computational model of H5N1
    avian flu hemagglutinin binding to avian and
    human type sialosides
  • Verify by re-docking experiment in AutoDock 4
  • Define intermolecular interactions changed by
    mutations introduced in silico (using Modeller)
    to hemagglutinin
  • Results may explain previously published in vitro
    findings

3
Progress
  • Receptor model possibly erroneously deformed
    after simulating pH
  • Blue indicates deviation in structure after
    simulating crystallization pH.

4
Further Plans
  • Literature research to further understand the
    receptor binding domain and this specific crystal
    structure
  • I have developed right ulnar nerve neuropathy and
    have to work 2 hours or less per day with a
    computer until symptoms subside, so journal
    research will be printed for reading

5
Trip to Beidaihe
6
Weekend Trip to Beidaihe
  • We trained to a famous beach resort town on
    Chinas northeast coast with two Chinese students
    at CAS
  • Most vacation spots in China are tacky and
    polluted (although often with breathtaking
    vistas)
  • Beidaihe was no different
  • More photos of delicious food and the sights are
    at http//picasaweb.google.com/feralryan/

7
Delicious shellfish is the number one
non-historical attraction of Beidaihe
8
Speed-boating to Old Dragon Head (where the
Great Wall hits the ocean) was Sundays highlight
tourist adventure.
9
One of the names for white people in Chinese is
white devil.
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