Integrating Molecular and Electrophysiological Views

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Integrating Molecular and Electrophysiological
Views Sept. 19, 2006 Receptor
Properties Gating Voltage - Ligand Ion
Specificity Cation or Anion Individual
Ion Inactivation Sodium Channels Potassiu
m Channels    Ion Channel States During the
Action Potential  
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Properties of Ion Channels True vs
Pseudo-subunit structure Channel Gating
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Fig. 3.6
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Fig. 3.6
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Fig. 3.3
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Fig. 3.1
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Fig. 3.4
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Fig. 6.11
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Kandel Essentials of Neural Science and Behavior
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In-class Exercise 1

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Properties of Ion Channels Ion
Selectivity Amazingly Fast Passive
What properties of ions can be used?
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Fig. 3-7
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Effect of hydration on size and mobility of
cations
ion atomic weight crystal radius hydrated
radius mobility Li 6.9
0.60 Å 4.5 Å
4.0 Na 23.0 0.95
3.4 5.2 K
39.0 1.33
2.2 7.6

in an electric field
Na
K
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Kandel Principles of Neuroscience Fig. 6.1
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Cation or Anion Specific Channels
Kandel Principles of Neuroscience
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Properties of Ion Channels Channel Inactivation
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Kandel, Priciples of Neural Science
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Siegel, Basic Neurochemistry Figure 6-8
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Fig. 6.12
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In Class Exercise 2
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Putting it All together Integrated Views of the
Action Potential
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Darnell Fig. 21-14
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In-Class Exercise 3
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Fig. 6.6