MatolKm In the World of Nutrigenomics

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Matol/Km In the World of Nutrigenomics

• Molecular Nutrition to Prevent Disease
• Kristine L. Clark, Ph.D., R.D.
• Matol Health and Nutrition Board Member

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Nutritional Genomics(Nutrigenomics)

• Definition the junction between diet, health,
  and an individuals genetic profile
• Tissue and organ inter-relationships affected
  by specific nutrients and food chemicals

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Antioxidants and InflammationConnection?

• Antioxidants
• disease prevention

• Inflammation
• disease promotion

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What are Antioxidants?

• Disease fighting chemicals
• Thousands exist - not all discovered yet
• In the body selenium, glutathione peroxidase
• Common ones Vitamin A, beta- carotene, Vitamin
  C, and Vitamin E (most potent)
• Predominantly found in plants

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Why are Antioxidants Important?

• Prevent inflammatory responses
• Today Inflammation is being called the root of
  all life-threatening diseases
• Heart disease
• Cancers
• Diabetes
• Obesity

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• New research at MIT may help scientists better
  understand the chemical associations between
  chronic inflammation and diseases such as cancer
  and atherosclerosis.
• When an infection occurs, immune cells flock to
  the area and secrete large amounts of highly
  reactive chemicals to combat the invader. But,
  these inflammatory chemicals also attack normal
  tissue surrounding the infection and damage
  critical components of cells, including DNA.
  During chronic inflammation, that damage may lead
  to mutations or cell death and even to cancer and
  other diseases.

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Research Definitive

• Nutritional antioxidants and the modulation of
  inflammation theory and practice. Grimble RF
• .Institute of Human Nutrition, University of
  Southampton, UK.
• Highly potent substances are produced by the
  immune system. These substances include cytokines
  and oxidant molecules, such as hydrogen peroxide,
  free radicals, and hypochlorous acid.
• The purpose of immune cell products is to
  destroy invading organisms and damaged tissue,
  bringing about recovery. However, oxidants and
  cytokines can damage healthy tissue.
• Excessive or inappropriate production of these
  substances is associated with mortality and
  morbidity after infection and trauma, and in
  inflammatory diseases. Oxidants enhance
  interleukin-1, interleukin-8, and tumor necrosis
  factor production in response to inflammatory
  stimuli by activating the nuclear transcription
  factor, NF kappa B. Sophisticated antioxidant
  defenses directly and indirectly protect the host
  against the damaging influence of cytokines and
  oxidants. Indirect protection is afforded by
  antioxidants, which reduce activation of NF kappa
  B, thereby preventing up-regulation of cytokine
  production by oxidants. Cytokines increase both
  oxidant production and antioxidant defenses, thus
  minimizing damage to the host. While antioxidant
  defenses interact when a component is
  compromised, the nature and extent of the
  defenses are influenced by dietary intake of
  sulfur amino acids, for glutathione synthesis,
  and vitamins E and C. In animal studies, in vivo
  and in vitro responses to inflammatory stimuli
  are influenced by dietary intake of copper, zinc,
  selenium, N-acetylcysteine, cysteine, methionine,
  taurine, and vitamin E.
• Information from animal studies has yet to be
  fully translated into a clinical context.
  However, N-acetylcysteine, vitamin E, and a
  cocktail of antioxidant nutrients have reduced
  inflammatory symptoms in inflammatory joint
  disease, acute and chronic pancreatitis, and
  adult respiratory distress syndrome. Impaired
  antioxidant defenses may contribute to disease
  progression after infection with human
  immunodeficiency virus. Powerful arguments have
  been advanced for treatment with antioxidants to
  slow progression of acquired immunodeficiency
  syndrome.

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Immune System

• The immune system has a remarkable ability to
  defend itself
• Plant chemicals are part of defense system

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Matol/Km as Immunotherapy tofight
inflammation

• Immunotherapy - to boost immune response
• 14 unique botanicals contribute over 100 specific
  antioxidant rich plant chemicals
• Natural biological substances

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Matol/Km offers an abundance of
antioxidants, NOT FOUND IN FOODS COMMONLY
EATEN.
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Matol/Km An Herbal Formula of 14 plant
extracts

• Sarsaparilla Root
• Passion Flower
• Senega Root
• Licorice Root
• Horehound
• Thyme
• Celery Seed

• Angelica Root
• Camomile
• Alfalfa
• Dandelion Root
• Gentian Root
• Saw Palmetto Berry
• Cascara Sagrada

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1. Sarsaparilla

• Anti-rheumatic, antiseptic, antipruritic,
  improves appetite, improves psoriasis, shows
  liver protection and anti-inflammatory properties
• Active chemicals in the plant Quercetin,
  phytosterols, and saponins.

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2. Angelica
Inhibits platelet clumping, can lower prothrombin
time. Active chemicals in the plant
Alpha-angelica lactone and coumarins.
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3. Alfalfa
Decreases plasma cholesterol and cholesterol
absorption increases excretion of bile acids and
neutral steroids may reduce blood sugar levels
(diabetes) has antifungal properties. Active
chemicals in the plant Saponins (cholesterol
lowering), medicagol (antifungal), coumetrolk
genistein, biochanin A, and diadzein.
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4. Dandelion Root
Diuretic, mild anti-inflammatory, slight laxative
effect, appetite-stimulating. Active chemicals
in the plant Sesquiterene lactones,
eudesmanolides.
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5. Gentian Root
Can increase digestive juices and saliva, some
anti-inflammatory properties, has constituent in
it to combat mosquitoes. Active chemicals in the
plant Gentiamarn, gentiopicrin, amarogentin,
swertiamarin, gentisin, isogentisin.
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6. Saw Palmetto Berry
May reduce "benign prostatic hyperplasia",
anti-inflammatory. The chemicals of benefit are
in the berry but have not been isolated and
identified yet.
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7. Horehound
Vasodilation, expectorant, antioxidant
properties. May normalize cardiac arrhythmias,
may reduce intestinal spasm, anti-inflammatory
properties. Active chemicals in the plant
Bitter compounds called marrubiin, volatile oils
like hydroxycinnamon, and tannins.
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8. Licorice Root
Anti-spasmodic, anti-inflammatory, laxative,
soothing properties, has anti-estrogenic
activity, can inhibit the Epstein-Barr virus,
significant anti-microbial activity against many
microbes, can accelerate the healing of peptic
ulcers. Active chemicals in the plant
Glycyrrhizin, glycyrrhetinic acid, isoflavinoids
(glabridin, glabrol), isoliquiritigenin.
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9. Senega
Expectorant, emetic activity, anti-inflammatory
(may be effective against graft rejection,
eczema, psoriasis, and multiple
sclerosis). Active chemicals in the plant
Salicylic acid, methylsalicylate, saponin mixture
called senegins (triterpenoids).
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10. Thyme
Antispasmodic, antitussive, and expectorant
effects anti-flatulent astringent
antibacterial stimulates saliva. Active
chemicals in the plant Thymol, carvacrol,
flavonoid constituents (rosmarinic acid),
phenolic compounds and volatile oils.
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11. Passion Flower
Sedative, anti-spasmodic, pain relieving
properties may raise the pain threshold has
anti-bacterial anti-fungal activity. Active
chemicals in the plant Apigenin, maltol,
ethylaltol, harmon alkoloids (harmine, harmaline,
harmalol, harman, harmin), passicol.
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12. Celery Seed
Sedative, anti-spasmodic, diuretic, hypotensive,
hypoglycemic effects, anti-platelet clumping
activity. Active chemicals in the plant
Phthalide constituents (d-limonene, selinene),
apiogenin
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13. Camomile

• Orally used for flatulence, travel sickness,
  nasal inflammation, GI spasms, cramps, diarrhea.
• Anti-inflammatory anti-allergic properties are
  due to azulene components in plant which
  inhibit histamine production
• Sesquiterpene bisabolol components have
  anti-bacterial, anti-ulcer, and anti-inflammatory
  properties.
• Coumarin components have anti-bacterial activity.

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14. Cascara Sagrada

• Orally used as a laxative. Also used for liver
  ailments, gallstones, cancer.
• Cascara has FDA approval for use as a
  non-prescription medication.
• Cascara contains Anthraglycosides which
  stimulate the colon to evacuate contents. It
  does not effect small intestine, only large.

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Matol/Km Nutrients to Promote Optimal Health

• Anti-inflammatory nutrients found in active
  herbal compounds
• Nutrients that interact with cell structures to
  reduce unhealthy cell mutations

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Bottom Line

• Reduction of Disease Risk Factors
• Promotion of Optimal Quality of Life