DIG for Disease Informatics Group

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DIG for Disease Informatics Group
RP Deolankar
oonnatie_at_yahoo.com
Smoking is injurious to health
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Honorable Mr. Bill Gates revolutionized IT
industry
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Dr. Vijay Bhatkar proved to be supercomputer
superman
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Prof. Kolaskar popularized bioinformatics
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Now, We are waiting for somebody To develop
Disease Informatics. What it is?
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Wealth Lot of health can be acquired Because
health is wealth
? ? ? ? ? ?
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Measure If Health is wealth Then Fitness is money
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Health Currencies Say Fitness dollars Measures
health
F
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Health Account Scene-1 Expenditure of F gt Bank
Balance in F Hardship!!! Disease Dis Ease
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Health Account Scene-2 Expenditure Bank
Balance No hardship No disease but Predisposed
to the disease or Not really healthy
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Health Account Scene-3 Requirement 1 fitness
dollar, Balance 10 fitness dollars Comfortable,
but Poor than the one having 100 fitness
dollars Disease and health are quantitative
concepts Not quantal Expressed in relative terms
100Fgt10Fgt1 F
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Health Account Scene-4 Fakir without a dollar is
much happier than Millionaire It is human to
make error in defining the disease
We seek, but never find, absolute truth
http//www.wordinfo.info/words/index/info/view_uni
t/1/?letterBspage3
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Definition of elephant by consensus panel
http//www.wordinfo.info/words/index/info/view_uni
t/1/?letterBspage3
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Last scene Man laid 50 in oven and 50 in
freezer Not comfortable, on an average Both the
gadgets must be tuned for the man Disease and
health are holistic concepts
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200
-200
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Health means whole Old. English word. hælþ
indicates wholeness Whole is not finite and
difficult to measure Measurement of fitness is
common We can ask the question Fit for what?
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General Holistic definition of health Health is a
state of Physical, Mental, Social, Emotional and
Spiritual wellbeing and not merely the absence of
disease
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Relevance of Health definition Doctors, Social
Workers, Educationists and Spiritual
Leaders contribute to the health of society and
treat diseases
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Limitation of the definition of health Health is
a STATE of absence of disease State indicates
static Health is dynamic, it flows, and it is a
process
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Adding dynamism Let us say, Gaining health is a
progression towards wellbeing and Loosing health
is a progression towards disease
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Modern definition of health Hence, health is a
process of gaining of Physical, Mental, Social,
Emotional or Spiritual wellbeing
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Let us hope that we have defined health
successfully
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Health happens to an individual Individual
Wellbeing Disease Loosing the proportion of
wellbeing is loosing the health and
proportionally gaining the disease
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Health examination of an individual It is
revealing certain events in the health history
of an individual
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• Three aspects of health examination
• Attempts to hunt priors (Backend events)
• Understand present (Current event)
• Predict posteriors (Front-end events)

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Point on the curve Events are sections of chains
in between Wellbeing of an individual and
Disease
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Ends of the chains are infinite Complete
wellbeing and complete disease are difficult
to define
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Events Movement of process from wellbeing to
disease can thus be judged by events
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Events have depth too Mild Disease is different
than Severe Disease
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Disease causal chains Events linked together form
the Disease Causal Chain or Web This chain can be
reversed sometimes
http//bmj.bmjjournals.com/cgi/eletters/326/7394/8
65
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Disease Causal Chains can be presented in tabular
format
 
http//bmj.bmjjournals.com/cgi/eletters/328/7443/8
11105704
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Database for events
The software should be derived to set aside the
combination terms (anatomical
physiopathological) from MeSH database of NCBI.
This will provide the database for events
occurring in the DiCC.
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Meta-analysis (Systematic Reviews) Source of
priors It is practice of combining the results
of a number of studies that address a set of
related research hypotheses
Professor Archibald Leman Cochrane
http//www.cochrane.org/index.htm
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Disease causal chains (DiCC) and Bayes DiCC has
priors and posteriors It is cake of Bayesian
rather than frequentists Synthesize evidence
from multiple sources Pilot studies Trials of
similar interventions Subjective judgments about
the generalisability of the study's
results http//bmj.bmjjournals.com/cgi/content/fu
ll/319/7208/508
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Factors Certain factors are associated with
movement of process from wellbeing to disease,
which are known as risk factors or protective
factors depending on the direction of movement
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Factors are variables Most of the time, same
factor could be risk or protective depending on
its magnitude and deviation from homeostasis
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http//ajp.psychiatryonline.org/cgi/content/full/1
58/6/848/F1
Helena Chmura Kraemer
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Human individual Disease happens to an
individual We need to understand What the human
individual appears like?
Baba Ramdev
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Model Human Somatic body Vitality Mind
Intellect Bliss
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Human body computer Intellect (Central
processing unit) Self / Ego (Software)
Memory (Free space, Floppy/ Hard disk) Mind/
senses (Program) Life history (Data)
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Human microbial organs Gut associated microbiota
organ Vagina associated microbiota organ Skin
associated microbiota organ
Prof. Stig Bengmark
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Study on human (Clinical Research) To understand
the disease of an individual One has to
understand the human and His body computer His
associated organs
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Let us summarise, What we have discussed about
disease till now
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Point no. 1 Absence of perceptible disease may
not be equated to health but lacunae in health is
disease
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Point no. 2 Disease may not be apparent when
predisposing events occur
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Point no. 3 In short, we all are walking on the
path today that may result in disease of tomorrow
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Point no. 4 However, bypassing the disease is
possible sometimes So as to avoid the diseases
of tomorrow we must act today
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Point no. 5 Disease predisposing events may not
be perceptible easily and may not get attention,
however, are real stem of disease causal chain
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Point no.6 Disease is a relative phenomenon,
could mean different to different thinkers, and
errors could be rampant in defining the diseases
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Point number 7 Disease Informatics Group has to
develop health-scoring system
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Point no. 8 If disease is present then Gravity of
the disease matters