Cardiac conduction system

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Cardiac conduction system
Sinus node
Left atrium
AV node
Bundle of His
Right Ventricle
Bundle Branches
Left Ventricle
Purkinje Fibers
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Cardiac impulse propagation
Left Atrium
Sinus Node
A-V Node
Left Ventricle
Right Atrium
Guyton and Hall, 1996, Fig. 10-4, p. 125
Right Ventricle
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Action Potential

• Fast sodium current INa
• depolarization
• Slow calcium current ICa
• plateau phase
• Slow potassium
• current IK
• repolarization

S. Nattel, Nature 2002415219-226
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From Polygons to Bricks
From Polygons to Bricks, Chris Delnooz,
Masters Thesis CS, 2001
A Multilayered Polygonal Mesh for the Cellular
Bidomain Model, Marije Mulder, Internship
Report, 2004
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Human ventricular membrane model
Priebe and Beuckelmann, Circ Res
1998821206-1223 Bernus et al., AJP Heart Circ
Physiol 2002282H2296-H2308
Vmem
I to
I Na
I K
I Ca
I K1
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Endocard
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Midwall
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Epicard
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Left Ventricle (5 layers)
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Human ventricular membrane model
Priebe and Beuckelmann, Circ Res
1998821206-1223 Bernus et al., AJP Heart Circ
Physiol 2002282H2296-H2308
Vmem
I to
I Na
I K
I Ca
I K1
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Geometry of Human Ventricles
The Influence of Cardiac Wall Deformation on the
Genesis of the Electrocardiogram, Wilco Kroon,
Masters Thesis, 2004
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5-layer Mesh of Human Ventricles
Frans Kremers, Internship, 2006
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Endocard (right ventricle)
Frans Kremers, Internship, 2006
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Midwall (left and right ventricle)
Frans Kremers, Internship, 2006
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Epicard (ventricle)
Frans Kremers, Internship, 2006
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Representation of Purkinje system
Gijs Huisman, Internship, 2006