Making%20of%20new%20sapphire%20hip%20endoprosthesis.

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Making of new sapphire hip endoprosthesis.

• From science to business
• on October, 10 12, 2006
• Kiev
• Doctor of medicine Vladimir Tankut
• Tel. [phone]
• E-mail filippenko_at_valor.ua
• Sytenko Institute of Spine and Joint Pathology
• Ukrainian Academy of Medical Sciences
• Kharkov

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What is needed in the market?
The creation of biologically inactive,
wear-proof, inexpensive pair of friction in the
hinge of endoprosthesis of joint hip is topical.
Prevention of high concentrations formation of
tension and increasing of operating reliability
are the advantages of the offered construction.
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•   
• Brief technology description.
• The technology of endoprosthesis creation is
  based on the synthesis of scaffolding with
  following raising of sapphire crystal in
  laboratory conditions and its processing in
  order to create the spheres into hinge of
  artificial joint.

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Stage of development.

• Development types of hip endoprosthesis with
  sapphire-chirulene pair of friction are created,
  their preclinical appraisal was performed with
  positive results.

In two years after operation
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Who needs it how many will they need?
The necessity in new working-out is very high.
Patients with I1I-IV grade of hip arthrosis
require operations of hip replacement. The amount
of these operations is equal to 50 000 in Ukraine
annually, whereas about 1 million in the whole
world per year.
It is annually executed operations of hip
replacement
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What is my unique technology advantage?
The complete process of product manufacturing
(from the raw mining to the outlet of end
product) is set up there are customers for its
forth putting.
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Competitive matrix.
The cheapness (comparing with existing
analogues), overstability and durability of
material (sapphire), low coefficient of
friction, biochemical inactivity and
biocompatibility with human organism.
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How will I beat the competition?Plainness,
cheapness, originality of endoprosthesis
manufacturing.Opportunity for joint work.The
work requires the participation of technologists
and medical staff, for further improvement of
endoprosthesiss working-out and their clinical
appraisal.
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Proprietary information statement

• The technology material presented in this talk is
  available for licensing or joint product
  development.
• None of the slides contain any confidential or
  proprietary information which would prevent
  patenting the technology.

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Problem Description Market Need
Hip arthrosis is a severe chronic progressive
disease of hip joint, which leads to severe
disability in 70-80 cases. The incidence of
this disease among working population has
increased on 40-60 for the last 20 years.
Dynamics of increase of coxarthrosis
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Problem Description Market Need
Hip replacement is an effective and progressive
method for the treatment of coxarthrosis. The
pairs of friction in the hinge knot are imperfect
in the existing constructions of endoprosthesiss,
which lead to severe complication in 25 cases
10-12 years after joint replacement and require
repeated revision operations.
Long-Term Clinical Results Arthroplasty of the
Hip
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The destruction of polymer in the knot of
endoprosthesis friction
Problem Description Market Need
factor of destruction
Total wear-out of Teflon socket after 3 years
Total wear-out of Chirulen socket after 3 years
J.Charnley Low Friction Arthroplasty of the
Hip 1979.
Sytenko institute of spine and joint
pathology 2003
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Brief technology descriptionAdvantages
On a level with the highest world standards the
new technologies of the production of pure
furnace charge for the growing of crystals,
optimal technologies for the processing of
spheres and acetabulum of artificial joint made
from sapphire, for the production of friction
pair with minimal coefficient of friction in
hinge will be worked out. New unique design of
hip endoprosthesis using sapphire-sapphire
friction pair in hinge will be worked out and the
technique of operation will be improved. New
pathogeneticaly grounded approach to the carrying
out of clinical roentgenological and laboratory
investigation of patients with hip pathology will
be worked out new criteria for the updating of
indications for operation and rehabilitation
period will be designed.
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Experimental results
The change of coefficient friction for different
connections of materials
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Stage of development (clinical tests if medical)
and international patents
Pre-productions models of hip endoprosthesiss
with sapphire head and acetabulum are
manufactured, pre-clinical trials are carried
out. Clinical approbation of endoprosthesis with
sapphire head was carried out on 5 patients, 5
years follow-up after first operation, the
results are good. There 4 Declarative Patents of
Ukraine, no international patents.
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Targeted Market Segment
Patients with coxarthrosis of III-1V grade
require hip replacement. Among these people are
middle aged and able to work citizens who has the
pathology of hip due to its disease or injury.
About 15 000 of hip replacement are performed in
Ukraine per year, and about 1million all over the
world. The price of our endoprosthesis
construction is about 1 000 Euro, whereas
existent construction 1500 - 2500 Euro.
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Competition
Our competitors are firms that produce
endoprosthesis (1 in Ukraine and about 30 all
over the world). On the background of great
experience in sapphire production, carrying out
about 5 000 operations of primary and repeated
joint replacement using different design of
endoprosthesiss (including 5 with a sapphire
head), presence of experienced highly qualified
specialists we will work out an endoprosthesis
with sapphire friction pair, that will be
cheaper, more safety, solid and unsophisticated
in manufacture in comparison with the analogues
existing nowadays.
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Competitive Matrix
Important product or technology characteristics Sytenko Institute of Spine and Joint Pathology Ukrainian Academy of Medical Sciences Kharkov DePuy USA Zimmer USA
Endurance Saphire/saphire 0,02 per year Metal/polymer 2 per year Metal/polymer 2-3 per year
Coefficient of friction Saphire/saphire 0,001 Metal/polymer 0,058 Ceramics/polymer 0,080
Biocompatibility Absolute Incomplete from formation of toxic particles of friction of materials Incomplete from formation of toxic particles of friction of materials
Cost (euro) 1000 1800-3000 1500-2500
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Opportunities
The necessity to create a modern high-technology
manufacture of hip endoprosthesis with new design
and sapphire friction pair in hinge. Carrying out
of the design of endoprosthesis in order to get
the European and world level. Approximate cost of
project is equal to 300 400 thousands Euro.
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Contact information

• Doctor of medicine Vladimir Tankut
• Tel. [phone]
• Mob. Tel. [phone]
• E-mail filippenko_at_valor.ua
• Sytenko Institute
• of Spine and Joint Pathology
• Ukrainian Academy of Medical Sciences
• Kharkov

new sapphire hip endoprosthesis