Quiz Roles

1

• Molecular Biology Course

Quiz Roles
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2

• Molecular Biology Course

Quiz 4 Section M-O
50 min

1. (30) Describe the major differences between the
   prokaryotic and eukaryotic transcription. Give
   one example to illustrate that transcription of
   eukaryotic genes is much more complicated than
   that of the prokaryotic.
2. (20) Why many transcription factors contain
   DNA-binding domains? Is DNA binding domain alone
   can exert the activation or repression of the
   gene expression? Why?

3

1. (15) Which classes of bacterial RNA need to be
   processed to become functional, and how?
2. (15) What is a ribozyme, list all the ribozymes
   that involve in RNA processing, and briefly
   describe their roles in the corresponding RNA
   processing events.
3. (20) It is known that spliceosome carry out
   pre-mRNA splicing? Describe how the cis-acting
   elements included in the pre-mRNA and the
   transacting factors included in the spliceosome
   interact with each other to accomplish the
   splicing event.

4
6. One of the many surprises to come from the
various genome projects is that the number of
genes an organism has is not necessarily a good
predictor of its complexity. For example, humans
are clearly much more complex than nematode
worms, yet only have about 50 more genes. How
could splicing help resolve this paradox?   (20
points)
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