Hans Eggen

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Save laboratories for research and vaccine
production against various diseases

• Hans Eggen
• Senior Partner
• IttenBechbühl AG
• Bern Switzerland

Institute for chemistry ETH Zürich Switzerland
FLI in Germany
SLSSynchrotron Switzerland
Other Laboratories in Switzerland
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Zürich ETH University of Technology
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Save laboratories for. . . . . .

Education inSwitzerland

Characteristic
Standardlaboratory
ETH Chemistry
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Education

Characteristic
Standardlaboratory
All services from the ceiling
ETH Chemistry
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Save laboratories for Education
.

Result ?
Educationand basicresearch

Characteristic
Standardlaboratory
43 variations
University of Technology ZürichChemistryexterio
r view
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ResearchlaboratoriesinSwitzerland

SLSSynchrotronSwitzerland
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Save laboratories for Research

Research
Characteristic
Constant room conditions
SLSSynchrotronSwitzerland
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Save laboratories for Research

Research
Characteristic
High precision of research results
SLSSynchrotronSwitzerland
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Save laboratories for Research

Research
Characteristic
Constant room conditions
No effect from sunshine
SLSSynchrotronSwitzerland
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Save laboratories for Research
.
.
.
Result ?

Research
Characteristic
Constant room conditions
SLSSynchrotronSwitzerland
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Save laboratories due to the workof qualified
control laboratories

The next level of complexity concerns the
security

25 state controllaboratories in Switzerland
Characteristic
individualsun protection
Methodical check of Quality drinking
waterevery type of Food, Facilities
State laboratory St Gallen
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Save laboratories due to the workof qualified
control laboratories

25 state controllaboratories in Switzerland
Characteristic
Standard labs.
All installations from the ceiling
State laboratory St Gallen
Standard floor plan withall services
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Safety
Result ?
Security

.
State laboratory St Gallen interior view of
standard laboratories
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Save laboratories for research and vaccine
production

Top level of complexity
- Laboratories to experiment with contagious
virus
- Bio-Safety
- Security
Laboratories to prevent disasters

- Qualified staff and methods
- Special facilities
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Save laboratories for research and vaccine
production

Facing a list of problems
A) Virus diseases
There are many different types
B) Dimensions
How small is 20 nano meter ?
BSL 4
BS L 3
C) Category of Bio-safety level

BS L 2
BS L 1
A definition of tightness and methods
D) Production of vaccines
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Save laboratories for research and vaccine
production against . . . . .

Production of vaccines
Virus diseases
Not patogen for humans
Dangerous only for cows

Human patogen
FMD
Foot and Mouthdisease
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Save laboratories for research and vaccine
production against . . . . . .

Production of vaccines
Virus diseases
Human patogentype H5N1
Dangerous also for human beings

AVI
Avianinfluenza
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Save laboratories for research andvaccine
production against. . . . .

All cases since 2003
Map from February 2007
World map AVI
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Save laboratories for research andvaccine
production against. . . . .

31.1.2007
World map AVI Far east
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Save laboratories for research andvaccine
production against. . . . .

31.5.2007
H5 N1
World map AVI Far East
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Save laboratories for research and vaccine
production against . . . . . .

Virus diseases
cow
dimensions
Characteristic
bacteria
2 micro meters
A virus isreallyvery small
virus
20 nano meters
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Save laboratories for research andvaccine
production against. . . . .

H5 N1
20 nano meter
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Save laboratories for research and vaccine
production

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
A virus isreallyvery small
25
Save laboratories for research and vaccine
production

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
Air pressure from outside to the inside
A virus isreallyvery small
26
Save laboratories for research and vaccine
production

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
Air pressure from outside to the inside
2 times
A virus isreallyvery small
27
Save laboratories for research andvaccine
production Bio-safety levels

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Save laboratories for research andvaccine
production Bio-safety levels

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Save laboratories for research andvaccine
production Bio-safety levels

30
Save laboratories for research andvaccine
production Bio-safety levels

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Save laboratories for research andvaccine
production Bio-safety levels

32
Save laboratories for research andvaccine
production Bio-safety levels

33
Save laboratories for research andvaccine
production Bio-safety levels

34
Save laboratories for research andvaccine
production

Laboratory project in Switzerland
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Save laboratories for research andvaccine
production

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Save laboratories for research and vaccine
production

production
Characteristic
Room conditions
architectural solution
IVI
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Save laboratories for research and vaccine
production

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
All technical services within the containment
A virus isreallyvery small
41
Save laboratories for research and vaccine
production

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
All technical services within the containment
A virus isreallyvery small
42
Save laboratories for research and vaccine
production

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
All technical services within the containment
A virus isreallyvery small
43
Save laboratories for research and vaccine
production against . . . . . .

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
All technical services within the containment
A virus isreallyvery small
Complete redundancy required
There are 2 versions of every piece of
installation
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Save laboratories for research andvaccine
production

45
Save laboratories for research and vaccine
production

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
All technical services within the containment
A virus isreallyvery small
46
Save laboratories for research and vaccine
production

HEPA Filter

Virus diseases
cow
High EfficiencyParticulateAir
dimensions
Characteristic
bacteria
A virus isreallyvery small
virus
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Save laboratories for research and vaccine
production

Virus diseases
dimensions
Characteristic
Bio safety 99.997
A virus isreallyvery small
48
Save laboratories for research and vaccine
production against . . . . . .

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
All technical services within the containment
A virus isreallyvery small
49
Save laboratories for research and vaccine
production

Virus diseases
The answer is
Containment technique
dimensions
The box in the box
Characteristic
A virus isreallyvery small
but a dead cow to be dissolved is a very
largething.
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Save laboratories for research andvaccine
production

Strict separation of clean and dirty corridors
Containment
Supply with clean material
Discharge of infected material
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Save laboratories for research andvaccine
production

Clean corridor
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Save laboratories for research andvaccine
production

Clean corridor
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Save laboratories for research andvaccine
production

Containment
Supply with clean material
Discharge of infected material
Air locks
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Save laboratories for research andvaccine
production

55

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Save laboratories for research andvaccine
production

What is different for an actual project ?
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Rügen
Rügen
Stralsund
Riems
Greifswald
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Insel auf dem Riems
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Insel auf dem Riems
Friedrich Loeffler Institut
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61

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production

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Save laboratories for research andvaccine
production

27
230 m
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production

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Save laboratories for research andvaccine
production to avoid risks

Air cond.
Electrical
Sanitary
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production

Vision of future laboratories ?
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production

Laboratory dress ?
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production

Fresh air access from the ceiling
Plus individual live support systems included
in each dress
communication
individual HEPA exhaust filters
individual fresh air filters
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Save laboratories to prevent disasters

Summary
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Save laboratories to prevent disasters

Summary
- The future is reality and has started long ago
- First of all trained staff is needed for each
speciality
- Complex requirements can be solved but . . .
. .
- only few companies full fill the conditions

• It is difficult to design and to imagine all the
  future
• requirements of the operation. . . . . . .
  . . ..

- also for maintenance and repair
-It is even more demanding to control the
productionprocess and the construction on site,
.
to avoid risks
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Save laboratories to prevent disasters

WHO Publication on Internet from 31.5.2007
AVI H5 N1