Systems

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Systems Behavioral NeurosciencePSB5341-01
Reproduction

• Rob Contreras
• Professor of Psychology and
• Director, Program in Neuroscience
• contreras_at_psy.fsu.edu

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Sexual Development

• Sexual dimorphism
• gonad
• internal genitalia
• external genitalia
• brain
• Female development - default pathway
• Typical and atypical pathways

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Alfred Jost's experiments on rabbits
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Chromosomal Anomalies

• Turners syndrome
  Klinefelters syndrome

XXY genotype SRY male Internal sex OK Small
testes Low T Low sperm gynecomastia
X0 genotype Poor ovaries Low hormone Immature
sex infertile
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Genetic basis of sex determination
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Molecular genetics of gonad development
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Gonadal Intersexuality ("True Hermaphroditism")
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Migrating germ cells
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X inactivation
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Development of male and female reproductive tracts
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Androgen Insensitivity Syndrome

• Nongonadal
• XY
• Mutation T-receptor
• Insensitive to T
• Normal testes
• AMH T
• Woffian fail
• External fail
• Complete/partial

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Development of male female external genitalia
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Development of male female external genitalia
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Congenital Adrenal Hyperplasia

• Genetic defect
• Corticoid synthesis
• Adrenal cortex
• Deficit corticoids
• Excess T
• XX
• No AMH
• Wolffian Duct
• External genitals
• masculinized

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5alpha-Reductase Deficiency

• Child at birth
  Appearance at puberty

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Hypospadias

• Male problem
• Urethra -
• Not enclosed
• Urination
• Ejaculation
• Cause?
• Surgery

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Descent of the testes
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Descent of the testes
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Third interstitial nucleus of the anterior
hypothalamus (INAH3)
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Development of sexual dimorphism of rat spinal
nucleus of the bulbocavernosus
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Sexual differentiation in hypothalamus
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Copulating rats
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Hormones and sexual behavior in rats