Purpose

1
INDIVIDUALIZATION OF THE TREATMENT IN PATIENTS
WITH ROSACEA USE OF DERMOCOSMETIC VEHICLES IN
COMPOUNDING
Francesc LLambí1, Anna Codina1, Anna
Viscasillas2, Alfons del Pozo2 1 Aprofarm.
Barcelona. 2 Unitat de Tecnologia Farmacèutica.
Facultat de Farmàcia. Barcelona

• Purpose
• To analyze the interest of the use of
  individualized formulations and adapted
  application forms, prepared from conventional
  active ingredients and dermocosmetics excipients
  for the initial and maintenance treatments
  (between the corresponding applications for the
  treatment selected) for patient affected with
  rosacea.

ROSACEA
Chronic process Location face central area
Symptoms
erythema telangiesctasia papules and pustules
extremely reactive and intolerant skins
?
oral
?
?
treatment
?
topic
Tested compounds
?
W/S moisturizing emulsion
tested effectiveness
METRONIDAZOL
?
Pharmaceutical specialities
In case of cutaneous intolerance problems
Compounds
O/W gel-cream

• 0,7-3 adapted to the patient by the
  dermatologist
• Dosage form EMULSION
• Classic basis (pharmacopoeia) Beeler Base
  (anionic)
• W/S basis
• O/W Oil free
• O/W Glucidic basis
• O/W Cremigels
• ? Pleasantness perceived by patient (cosmetic
  emollients)
• ? Reologic properties (touch, extensibility,)
• Possibility incorporation of coadjuvants
• Vascular tonic (ruscus extract,
• Antiinflammatory, antich (enoxolona, ictiol)
• Solar filters (SPF 20 ? winter)
• (SPF50 screen total?extended
  exposure)
• Epithelium-restoring agents (allantoine..)
• modulation seasonality/climatology
• W/S Glucidic basis emollients of low
  occlusivity. Interest in cold and dry climate and
  winter.
• Cremigels minimally occlusive, refreshing,
  hygroscopic, avoid the excessive dehydration in
  summer, avoid retention of the sweat in the
  treated surface that could be irritating.

Glucidic moisturizing emulsion (sprayable)
Dermocosmetic excipient Physical stability gt 9
months at 30ºC