Prostaglandinsynthese

1
Influence of Flaxseedoil and Fishoil on
metabolism of fatty acids
ICAK Meeting 2006, Wien
Dr. Harald Stossier VIVA Das Zentrum für
MODERNE MAYR MEDIZIN A 9082 Maria Wörth,
Seepromenade 11 stossier_at_viva-mayr.com
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Prostaglandinsynthesis
Enzyme
?-3 FA
?-6 FA
Linoleic Acid 182
Linolenic Acid 183
B3, 6, Mg, Zn, C, Biotin
d-6 Desaturase
GLA 183
ODTA 184
B3, Zn, C,
Elongase
ETA 204
DHGLA 203
B3, 6, Mg, Zn, C, Insulin
- EPA, Glucagon
d-5 Desaturase
Cyclooxygenase
AA 204
PG 1
EPA 205
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Prostaglandinsynthesis
DHGLA 203
Arachidonic Acid 204
B3, 6, Mg, C, GSH, Alk, E ?
Lipoxygenase
Cyclooxygenase
- Vit E ?, NSAR, Aspirin
- DHGLA, Boswelia
Leukotriens
PG 2
PG 1
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Question
Is the intake of flaxseed oil correlated with an
increase of EPA und DHA? Are there therapeutical
consequences?
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Studydesign
20 participants have eaten no fat first, than
flaxseed oil and later fishoil in therapeutical
dosages.
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Studydesign
2 weeks nutrition without fat 1. Bloodcheck
Faty acids 6 weeks 2 TS flaxseedoil / day 2.
Bloodcheck Faty acids 2 weeks break 3.
Bloodcheck Faty acids 6 weeks 2 g EPA / DHA per
day 4. Bloodcheck Faty acids
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Studydesign
The fatty acid metabolism was reported before and
after the intake of flaxseed oil and fishoil in
the serum and Ery, afterwards statistical
evaluations
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Studydesign
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Results
The intake of flaxseed oil leads to an
significant increase on LNA und EPA in Erys
Serum, but not on DHA
Linolenacid
EPA
DHA
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Results LNA-EPA-DHA
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Results
The intake of flaxseed oil shows an significant
decrease of AA in Serum, but not in Erys
DHGLA
EPA
AA
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Results - AA
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Results
The intake of flaxseed oil shows an significant
improvement in the proportion of?-6 ?-3 EPA
AAin Erys Serum
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Results ?6 ?3
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Consequenses
The intake of flaxseed oil in many cases is equal
to the medication of fishoil in capsules and
therefore a meaningful nutritional
recommendation
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Thank you for your attention and ENJOY THE
OIL