ACIS III Image Analysis

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ACIS IIIImage Analysis

• Robert Carlson
• Manager, Imaging Systems

Accurate Efficient Consistent
Easy to use
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DAKO 40 Years Experience in AP MarketplaceFrom
Antibodies to System Solutions
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Addressing Your Challenges
Quality

• Cost and Productivity

• Turn Around Time

• Utilize labor time more efficiently
• Simplify ordering processes
• Streamline workflow

• Eliminate redundant tasks
• Process simultaneously

• Reduce repeats
• Improve consistency
• Implement cutting-edge technologies

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ACIS III is Accurate

• Proprietary, color-based image analysis software
  combined with Whole Slide Scanning automated
  microscopy
• FDA Cleared Applications
• HercepTestTM for HER2
• ER
• PR
• Additional applications
• Generic applications (Membrane, Nuclear,
  Microvessel Density, Ploidy, Rare Event)
• Tissue Micro Array (TMA)
• Flexible solutions to meet unique research needs

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ACIS III is Efficient

• Technician Operation
• Automated calibration (10 min., once every 24
  hours)
• Accessioning
• Dako LINK software Integration
• ACIS III accessioning screen
• Automated processing of slides
• High capacity (100 slides)
• Continuous access 24 hours a day
• Immediate access to digital slides for scoring
• Analysis of digital slides by pathologist
• Need a quick consult or second opinionuse Dako
  EyeShareTM
• Report generation by pathologist or technician

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ACIS III is Consistent

• Gold Standard Calibration
• Daily, one-touch calibration ensures proper
  focus, color balance and light intensity
• Calibration does not require additional
  pathologist time
• ACIS III improves inter-observer reproducibility
  with consistent stain intensity scoring

Proper calibration helps ensure laboratory
results are consistent
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ACIS III is Easy to useSoftware

• 4-tab Dako software format
• Accessioning
• Microscope
• Analysis
• Report
• Easy to use
• Reduces training time
• Reduces hands-on time

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Dako EyeShare

• Remote Slide Viewing Software via the internet
• Live Consultation
• Second opinions
• Teaching
• Standardization

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ACIS Proven Performance Sample Article Listing

• Most peer reviewed imaging system on market
• ACIS Selected Article Bibliography
• Automated System Improves Accuracy of HER-2
  Scoring. ONI, April 2001.
• Ayala G, Wang D, Wulf G., Frolov A, Li R,
  Sowadski J, Wheeler T, Lu K, Bao L. The Prolyl
  Isomerase Pin1 is a Novel Prognostic Marker in
  Human Prostate Cancer. Cancer Research 2003 Vol.
  63, 6244-6251.
• Bauer KD, Torre Bueno, J, Diel IJ, Hawes D,
  Decker WJ, Priddy C, Bossy B, Ludmann S, Yamamoto
  K, Masih AS, Espinoza FP, and Harrington DS.
  Reliable and Sensitive Analysis of Occult Bone
  Marrow Metastases Using Automated Cellular
  Imaging. In Autologous Blood and Marrow
  Transplantation X Proceedings of the 10th
  International Symposium (K.A. Dicke and A.
  Keating, eds). 2001. Carden Jennings Publishing
  Co., Charlottesville, VA, 672-687.
• Becker S, Becker-Pergola G, Fehm G, Emig R,
  Wallwiener D, Solomayer E-F.   Image Analysis
  Systems for the Detection of Disseminated Breast
  Cancer Cells on Bone-Marrow Cytospins.  Journal
  of Clinical Laboratory Analysis 19115119, 2005.
• Birner P, Ritzi M, Musahl C, Knippers R, Gerdes
  J, Voigtlander T, Budka H, Hainfellner J.
  Immunohistochemical Detection of Cell Growth
  Fraction in Formalin-Fixed and Paraffin-Embedded
  Murine Tissue. Am J Pathol 2001 Vol. 158,
  1991-1996.

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Summary of Key Benefits of Dako Solution
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