713 Lecture 12

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713 Lecture 12

• Applied metagenomics

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Industrial applications

• Bioremediation
• Biofuels (ethanol production)
• Biocatalysis (novel enzymes)
• Medicine
• Probiotics among commensals
• Competitors/antagonists of pathogens
• Polymicrobial disease

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More on the mammalian gut microbiome

• Adult monozygotic twins (and, to a lesser extent,
  dizygotic twins and siblings) have more similar
  gut microbes than to their marital partners
• Animals inherit their gut flora from their
  mothers
• Host genotype appears to affect relative
  abundance of community members, not composition

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Mouse vs Fish

• 99 of mouse gut bacteria belong to Bacteroides
  and Firmicutes
• Mostly Proteobacteria in Fish
• Do gut bacteria differ because the residents of
  their typical environment differ?
• Or does the host animal select the resident
  bacteria?

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