Future Research Group F Splenectomy

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Future ResearchGroup F - Splenectomy
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Guidelines for Splenectomy Management???

• Have considerable power legally
• Must be based upon evidence-based medicine
• We favor a survey of practice regarding
  vaccination, antibiotic prophylaxis, timing of
  anti-CD20 and steroids prior to vaccination

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Survey Centers as to Protocol for Immunization

• gt2 weeks before splenectomy
• Pneumococcal
• H. flu
• Meningococcal
• EDUCATION
• Antibiotic prophylaxis
• Variable compliance

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ICIS Splenectomy Registry

• Genetic analysis for polymorphisms that might
  correlate with ITP failure of splenectomy
• Immune system
• Fc Receptor polymorphisms
• Etc.

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Evaluate Immune Function

• Pre- and post-splenectomy
• Use same vaccination protocol
• In vitro assays done in central laboratory
• Controls ???
• Titers against platelet antibodies do they
  change?
• Evaluate genetic susceptibility to encapsulated
  organisms
• ? Which markers

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?Thrombosis Post-splenectomy?

• Recommendation to screen post-splenectomy for
  portal splenic venous thrombosis
• Hypothesis is that there will be no increased risk

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QUALITY OF LIFE Measurements Should be
continued long term