Diagnosis of Multiple Sclerosis

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Diagnosis of Multiple Sclerosis

• David Allan Hughes
• david.hughes_at_strath.ac.uk

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Diagnosis of MS

• Complications
• Clinical
• Experimental
• MRI
• Oligoclonal Bands

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Complications

• Central nervous system disorder
• Any neurological symptom possible
• Overlap with other diseases
• Postmortem required for 100 diagnosis
• Uncertainty is common to all sufferers

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Clinical

• Diagnosis of MS is a clinical one
• Extensive patient history used
• Environment
• Lifestyle
• Family History
• Temporal and Spatial evidence required

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Magnetic Resonance Imaging

• High Resolution
• Different levels of sight
• Contrast Agents
• Gadolinium
• Compare contrasttwo levels of sight

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Oligoclonal Bands (OCB)

• OLIGO-few in number, CLONAL genetically identical
  items
• Arise due to immune system action
• Samples
• Blood
• Cerebral Spinal Fluid
• Analysed using electrophoresis

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Oligoclonal Bands
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Conclusion

• No definitive test
• New technology aids the diagnosis
• Lack of understanding of OCB mechanism

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References