Synaptic transmission

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Synaptic transmission
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Objectives

• What are the different kinds of synapses?
• What are the criteria that define a
  neurotransmitter?
• What are the classes of neurotransmitters?
• How does signal transmission take place at a
  synapse?

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Loewis experiment
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Neurotransmitter criteria

• Must be present in the presynaptic neuron
• Must be released in response to presynaptic
  depolarization and be Ca2 dependent
• Receptors for NT must be on postsynaptic cell
• Application of NT can mimic release
• Use of NT agonists and antagonists
• Histological studies

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Neurotransmitters

• Co-transmitters and differential release
• Low frequency activitysmall molecules
• High frequency activitypeptides
• Regulation of synthesis, packaging, release and
  removal

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EPPs and MEPPs

• End plate potentials (EPPs)
• Miniature end plate potentials (MEPPs)

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Quantal release

• MEPPs occurred in integer multiples of MEPP
  amplitude

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Recycling
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Recycling