Folie 1

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Organs affected with AIDS-lymphoid tissue
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HIV in the nervous system AIDS dementia
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Karposi Sarkoma

• First reported by Hungarian physician Moritz
  Karposi in 1872
• Multifocal cancer dominant type is called
  spindle cells endothelial origin
• Typically in older man in Mediterranian rim
• In HIV-1 very aggressive occurs in 20 of
  infected homosexual man, only 2 in others
• Evidence that Herpes virus (HHV8) is necessary is
  strong

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Karposi Sarkoma
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Karposi Sarkoma
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Treatment of AIDS

• HAART highly efficient triple combination
  therapy (2x anti-reverse transcriptase,
  1xprotease inhib.)

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Viral decay on drug treatment
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Resistance of HIV to protease inhibitors
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HIV Infection is spreading over all continents
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Immune Therapies/Prophylactic vaccine development

• Difficulties
• Rapid mutations in virus
• Danger to cause an inappropriate immune response
• Necessity to target privileged sites (mucosa,
  brain)
• Small animal models not available
• Ethical issues of vaccination people should
  adjust behaviour

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Perspectives

• Prevention!!!!!
• Multiple steps in viral replication offer new
  targets

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Innate ImmunityAdelheid Cerwenka, PhD, D080
Theodor Boveri-Group since April 2003 PhD
students Norman Nausch Kai Zanzinger Anja
Schmidtke Technician Sandra Kosten