Title: s70, s32, s54
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s70, s32, s54
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8Sp1
HSTF
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10Transfer RNA Precursor Processing. The conversion
of a yeast tRNA precursor into a mature tRNA
requires the removal of a 14-nucleotide intron
(yellow), the cleavage of a 5' leader (green),
and the removal of UU and the attachment of CCA
at the 3' end (red). In addition, several bases
are modified.
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13RNA Editing
14Dr. Richard Roberts and Dr. Phillip Sharp, Your
discovery of split genes led to the prediction of
a new genetic process, that of RNA splicing. The
discovery also changed our view of how genes in
higher organisms develop during evolution. On
behalf of the Nobel Assembly of the Karolinska
Institute I wish to convey to you our warmest
congratulations, and I now ask you to step
forward to receive the Nobel Prize from the hands
of His Majesty the King.
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20Self-Splicing. A ribosomal RNA precursor from
Tetrahymena splices itself in the presence of a
guanosine co- factor (G, shown in green). A
414-nucleotide intron (red) is released in the
first splicing reaction. This intron then splices
itself twice again to produce a linear RNA that
has lost a total of 19 nucleotides. This L19 RNA
is catalytically active
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