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Normal Cartilage

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... micrograph of human articular cartilage from the medial ... Chondrocyte clusters (arrows) are visible in the fibrillated. superficial layer of OA cartilage ... – PowerPoint PPT presentation

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Title: Normal Cartilage


1
Normal Cartilage
-Light micrograph of human articular cartilage
from the medial tibial plateau of a 45-year old
man. Weigerts acid iron chloride hematoxylin,
safranin-O and fast green stain (proteoglycan red
and collagen green)
Provided by Y Henrotin
2
Normal cartilage
B
A
C
  • Normal cartilage with chondrocytes isolated in an
    extended
  • extracellular matrix (A). The calcified cartilage
    layer overlying subchondral bone
  • (B). Normal subchondral bone (C).

Provided by Y Henrotin
3
Chondrocyte clusters in OA cartilage
  • Chondrocyte clusters (arrows) are visible in the
    fibrillated
  • superficial layer of OA cartilage

Provided by Y Henrotin
4
Subchondral bone sclerosis
  • Subchondral bone sclerosis (arrow) is
    characterized by trabecular
  • thickening, low mineralized osteoid substance
    accumulation and
  • osteoblasts phenotype alteration

Provided by Y Henrotin
5
Multiple Tidemark
- Multiple tidemark are visible in OA calcified
cartilage (multiple arrows)
Provided by Y Henrotin
6
Osteochondral plate microcracks
A
  • Subchondral bone sclerosis (A). Multiple
    microcracks
  • are visible at the bone/cartilage junctions
    (arrows)

Provided by Y Henrotin
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