Most Innovative New Product

1

• Most Innovative New Product
• UCSD CONNECT
• November 14, 2005
• David Wellis, PhD
• SVP, Marketing Sales

2
The Problem

• Unique identification of countless items has
  become a necessity across broad industries.
• There are few technologies that scale well beyond
  the millions

Forensics
Consumer products
Life sciences
3
GenVault Innovation - GenCode

• Limited set of synthetic DNA segments that differ
  in sequence and size and can provide unlimited,
  cost-effective unique identifiers.

4
Traditional Identification
Electronic coding

• Handwriting
• Serial numbers

Physical, hard coding
One dimensional
RFID
Two dimensional

• Limited in terms of reliability and expense.

5
Traditional DNA Identification

• DNA is the ultimate identifier
• Based on unique, but complex sequences of DNA
• Artwork
• Olympic souvenirs

• Limited in terms of cost of creating and
  reading
• large numbers of unique sequences.

6
Container Identification

• Most often the container is labeled, not the
  actual contents.
• Once the sample is removed from the container,
  the chain of custody is broken.

7
GenCode How it works
90 bp 50bp

• Sets of short synthetic DNA fragments
• Each fragment has a unique sequence and size
• Each set of 5 fragments generates 25 unique codes
• Five sets of 5 fragments generates 225 unique
  codes
• Integrity tested by check code

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GenCode How it works
1 1 1 1 1
0 0 1 0 1
1 0 0 1 1
0 0 1 1 0
1 1 0 0 0
0 0 1 1 1
5872391
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GenCode Utilized in GenPlates
Barcode on each plate
GenCode on each element
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Application in GenVault System
GenCode-embedded GenPlates, a component of a
fully-integrated sample management system.
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GenCode Advantages

• Inexpensive to produce
• Traditional barcodes are several cents each
• RFID tags are near 0.10, goal is 0.05 per item
• GenCode is currently 0.005 per sample
• Tamper proof with check sum
• Comigrates with biosamples during analysis for
  unbreakable chain of custody
• Decryption can be built-in to analysis
  platforms

12
GenCode Significance

• Sample misidentification becomes non-existent,
  providing
• Higher quality scientific results
• More robust correlations in life science research
• Priceless and rare samples are never lost
• A new level of quality control and assurance
• No patient sample mix-ups in the diagnostic lab
• Increased levels of correct convictions or
  acquittals in forensics/law enforcement
  applications

13
Market Potential

• Sample handling in life sciences and diagnostics
  is growing toward 10B in 2008.
• RFID market alone estimated to be 7B in 2008.

14
GenVault Innovation

• GenVault has leveraged DNA fragment size and
  sequence to produce GenCode, a highly unique
  identification technology.