I'Introduction to Hypertension

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I. Introduction to Hypertension II. Non-pharmaco
logical Therapies III. Physiological Regulation
of BP IV. Pharmacological Therapies A. ?-AdR
blockers B. Diuretics C. Ca channel
blockers D. ACE inhibitors E. CNS
sympatholytics F. Peripheral sympatholytics G.
Vasodilators
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IV. Pharmacological Therapies C. Ca-channel
blockers
used to treat hypertension, angina, and
arrhythmias
work by blocking Ca-influx in
from the Color Atlas, p. 123
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from Brody et al.
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from the Color Atlas, p. 123
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from Brody et al., Fig. 17-1
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from Brody et al., Fig. 17-1
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from the Color Atlas, p. 123
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Effects of Ca Channel Blockers in Heart
from Brody et al.
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Ca-channel blockers can be divided into at lease
two types vasoselective- non-vasoselective-

Verapamil for arrhythmias
Nifedipine, Nitrendipine, Felodipine for
hypertension angina
from the Color Atlas, p. 123
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a third type of Ca-channel blocker is diltiazem,
a benzothiazapine
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Diltiazem has the best properties of
the nifedipine- and verapamil-relatives can be
used for hypertension, angina and arrhythmias
with fewer side effects than the others
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from Brody et al. p. 211
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Nifedipine 9th most prescribed drug-
1996 http//www.rxlist.com/cgi/generic/nifedxl.htm
Verapamil gt50th most prescribed drug-
1996 http//www.rxlist.com/cgi/generic/verapsr.htm
Diltiazem 13th most prescribed drug-
1996 http//www.rxlist.com/cgi/generic/diltiaz.htm