Memory consolidation for simple sequencing behavior.

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Memory consolidation for simple sequencing
behavior.

• David L. Wright

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Memory Consolidation What is it?

• Stabilization consolidation increases a memorys
  resistance to competing memories
• Enhancement consolidation (EC) involves offline
  gains that are independent of physical practice

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Memory Consolidation What is it?
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Examples from our lab
Panzer et al., (2006) JMB, 38(1), 6070
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Another example
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Enhancement consolidation
Walker et al., (2003) Nature 425, 616-619
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Time course of consolidation
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Some Interesting Findings

• Need stabilization to obtain EC
• EC occurs over sleep not wake periods for
  explicit tasks
• Overnight EC gains correlate with Stage-2 NREM
  sleep
• Overnight EC is greater for more complex tasks
• EC benefits target the chunking process
• EC have been revealed for the spatial
  representation developed early in practice

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Need stabilization to get EC
Walker et al., (2003) Nature 425, 616-619
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EC occurs over sleep not wake periods for
explicit tasks
Walker et al., (2003) Nature 425, 616-619
11
Overnight EC gains correlate with Stage-2 NREM
sleep
Walker et al., (2003) Nature 425, 616-619
12
Overnight EC is greater for more complex tasks
Walker et al., (2003) Nature 425, 616-619
13
EC benefits target the chunking process
Walker et al., (2003) Nature 425, 616-619
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EC have been revealed for the spatial
representation developed early in practice
Walker et al., (2003) Nature 425, 616-619
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Early in learning when cognition seems more
crucial to learning

• EC occurs over sleep not wake periods for
  explicit tasks (excessive cognition interferes)
• Overnight EC is greater for more complex tasks
• EC benefits target the chunking process
• EC have been revealed for the spatial
  representation developed early in practice

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Use practice extent manipulation to address this
issue directly

• Does increasing practice extent influence
  performance benefits from EC?
• Assess whether EC interacts with practice extent
  (EC directly)
• Assess whether practice extent decreases
  vulnerability to interference (EC indirectly by
  influencing stabilization)

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Walker et al., (2003) 10 275-284 Learn. Mem.
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Additional training does not facilitate
enhancement consolidation
Walker et al., (2003) 10 275-284 Learn. Mem.
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