TNT: Incidence of elevated liver or muscle enzymes

1
TNT Incidence of elevated liver or muscle
enzymes
Treating to New Targets
N 10,001
Atorvastatin 80 mg ()(n 4995)
Atorvastatin 10 mg ()(n 5006)
ALT and/or AST gt3xULN
0.2
1.2
CK gt10xULN
0
0
4.8
Myalgia
4.7
Rhabdomyolysis
0.04
0.06
P lt 0.001 vs atorvastatin 10 mg ALT alanine
aminotransferaseAST aspartate
aminotransferaseULN upper limit of normal
LaRosa JC et al. N Engl J Med. 20053521425-35.