Learning Objectives: GI Drugs

1
Learning Objectives GI Drugs

• Describe the underlying mechanisms of disease
• Describe the role of histamine in GI disease
• Analyze SAR of H2 antihistamines, compare to H1
  antihistamines
• Describe therapeutic implications of histamine
  antagonism vs proton pump inhibition
• Show structurally how a proton pump is activated
• Recognize protective drugs and name them

2
Describe the underlying mechanisms of disease

• Peptic Ulcer Disease
• Gastroesophageal Reflux Disease
• Inflammatory Bowel Disease
• Crohns
• Ulcerative colitis

3
Role of histamine in GI disease

• Stimulation of ECL cell by gastrin releases
  histamine
• Histamine causes release of stomach acid

4
SAR of H1 and H2 antihistamines
5
Proton Pump Activation
6
Protective Drugs
Prokinetic drugs Stimulate gut motor function,
raise esophageal sphincter, speed passage of
stomach contents