DERMASILK

1
(No Transcript)
2
Skin and Fabrics

• Scientific literature confirms
• The bacteria easily colonize the fabrics as they
  find ideal environmental for their growth

• Food (dirt, fiber, perspiration)
• Warm temperatures
• Moisture (humidity, spills)
• Surface (skin, fabric)

Penecillium sp.
Our modern life and work style are beneficial for
microbial growth.
3
Where are microbes?

• Virtually everywhere
• In the air we breath
• On our skin and bodies
• In the soil
• On practically all surfaces around us

4
Microbial effects

• Microbial growth can result in
• Objectionable Odours.
• Unsightly stains.
• Allergenic responses.
• Disease and Infection Cross Contamination.
• Product deterioration.

5
What are the main benefits of the ÆGIS Microbe
Shield Technology?

• Maintains long-lasting freshness.
• Eliminates the smells created by yeast, fungus
  and bacteria in the product.
• Controls or eliminates microbial staining of the
  treated article.
• Reduces the risk of cross contamination.

6
Antimicrobial Agents

• Capable of destroying or suppressing the growth
  of microorganisms
• Differ in their
• Chemical Nature
• Mode of operation
• Durability
• Effectiveness
• Safety
• Cost
• Verification

7
Mode of operation Main Differention
MIGRATING or NOT MIGRATING
8
Conventional Antimicrobial

• Diffuse from the product to come in contact with
  the microbe
• Leach or migrate out of the product into the
  environment
• Are consumed by microorganisms
• Chemically interrupt (poison) the cell
• Can be used up
• Cause adaptive microorganisms
• No means of attachment

9
Zone of Inhibition
10
The Zone Of Inhibition Story
Zone of NO Inhibition
Zone of Inhibition
Lethal
Sub-Lethal
Toxic Chemical Concentration Gradient
Zone of Adaptation (Super Bug Zone)
C
11
Microbe Adaptation
Fully Adapted Cells with Ghost Zone
Adapting Cells in the zone
Initial Zone
12
Conventional Antimicrobials Examples

• Bis chlorinated phenols (triclosan)
• Organo tins (i.e.TBT)
• Heavy metals organo complexes (Pb,Hg,As,)
• Ag CU Zeolithes
• Biguanide
• Chitin

13
The Skin/Fabric environment
14
Unconventional Antimicrobial

• Are bound to the product requiring the microbes
  to contact it
• Are bounded to the product surface
• Are not consumed by microorganisms
• Mechanically interrupts (stabs) the cell wall
• Remain functional for the life of the product
• Will not cause adaptive microorganisms

15
The Skin/Fabric environment with ÆGIS Microbe
ShieldTM
16
The ÆGIS Microbe ShieldTM Molecule

• 3-(trihydroxysilyl) propyldimethyloctadecyl
  ammonium chloride

QUATERNARIUM AMMONIUM
SILANE Anchor Reacts with the fiber and itself
DURABILITY
17
PolymerisationMonomer Polymer

• Polymerises not only onto the surface of the
  fiber, but also to itself

C18
18
The cell membrane
C18
19
How does the ÆGIS Microbe ShieldTM works?
20
How does the ÆGIS Microbe ShieldTM works?
21
How does the ÆGIS Microbe ShieldTM works?
There are approximately THOUSAND swords available
for 1 microrganism
22
Only the microrganism who are in contact with the
substrate will be killed, not the needed
microrganism living on our skin
23
ÆGIS Microbe ShieldTM Non toxic and respect
for the environment

• The chemical bounding causes the surface to
  become antimicrobially active
• No migration on the skin
• No migration to the environment

24
Registration

• 3-(trimethoxysilyl) propyldimethyloctadecyl
  ammonium chloride

• C.A.S. Number 27668-52-6
• EPA Registration Nr. 34292-1
• European Notification N605
• Accepted on the Oeko Tex list of active chemicals

25
SILK
The Dermasilk line associates the benefits of the
silk with the antibacterial antimycotic action of
ÆGIS Microbe Shield
26
Why the silk?

• It is the most similar fabric to our skin, as it
  is presented a structure very similar to hair.
• It carries out natural protective alleviative
  action on the skin thanks to
• Thermoregulation function, maintains body
  temperature
• Softness
• Hygroscope capacity
• Breathtability

27
Why the silk?
The cotton carries out his hygroscopic capacity
irritating sensible skin. The cotton thread is
composed by million short threads (1-3 cm.) kept
together by spinning and characterised by
irregular and plant section.
Cotton
The cotton yarn is the unique able to adsorb and
transfer humidity without creating irritation,
but rinsing and reducing the diameter of the
cylindrical yarn long beyond 800 m.
28
ÆGIS Microbe Shield is anchored permanently to
silk yarn. When the microrganism comes in contact
with the treated fabric, it is killed by rupture
of the cell membrane.

• antibacterial/antimycotic action
• comfort

29
Scientific studies have been demonstrated the
efficacy of
- G. Ricci et al Clinical effectiveness of a
silk fabric in the treatment of atopic
dermatitis BJD 2004 150 127-131.
At the end of the study a significant decrease
in AD severity was observed in the children
treated with the silk clothes (DERMASILK)
- C Vinci et al Efficacia clinica del Dermasilk
nel trattamento delle ulcere diabetiche DM
2003 23211-220
Possiamo concludere che la medicazione con
Dermasilk è utile nel trattamento delle ulcere
nel piede diabetico.
- G Marcellini et al Studio sullefficacia di
indumenti intimi a base di seta medicata
(Dermasilk) in alcune affezioni ginecologiche
I benefici si manifestano rapidamente
(diminuzione del sintomo pruriginoso in pochi
minuti) in quanto la riduzione della
sovrainfezione batterica permette alla cute
irritata/lesionata di recuperare in breve tempo,
la propria funzione barriera.
30
Activity range of ÆGIS Microbe Shield