Adaptive Immunity: 2 Branches

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Adaptive Immunity 2 Branches
Humoral
Cell-mediated
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T-lymphocyte interacting with a macrophage
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Overview of Immune System
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MHC interactions
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Response to Ag (humoral system)
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Response to Ag (CMI system)
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Electrophoresis of serum proteins
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Generic Ab
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Ribbon diagram of a monoclonal ab
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IgG
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Variability of residues in different abs. The 3
hypervariable regions are termed
complementarity- determining regions (CDR)
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Side-view of Angiotensin II bound to Fab.
Van der Waals surface contacts
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Ab classes
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The Ig superfamily
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Organization and Expression of Ig Genes
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(human chromosome 22)
(human chromosome 2)
(human chromosome 14)
Gene arrangements
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Circular DNA isolated from thymocytes undergoing
TCR rearrangement (these rearrange just like Ab
genes)
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From Hozumi and Tonegawa, 1976, PNAS USA 73 3628
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Kappa gene expression
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H-gene expression
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Recombination signal sequences
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When ss DNA is generated
Extra nucleotides can also be added
Nucleotide addition during joining
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Somatic variation
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Allelic exclusion (only in B and T cells)
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Model of allelic exclusion
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Class switching
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Secreted vs. membrane forms of IgM
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Class switching by alternative processing
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Class switching by alternative processing
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Secretory pathway
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cis-acting sites