Title: Louis Pasteur watches a rabies vaccination
1Louis Pasteur watches a rabies vaccination
2Immunity 2 Branches 1. Non-specific Immunity
Examples?
2. Specific Acquired Immunity
Specific
Has memory
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4RBC
monocyte
Macrophage attacking E. coli
5 A macrophage interacting with bacteria
6Inflammation
7Adaptive Immunity 2 Branches
Humoral
Cell-mediated
8T-lymphocyte interacting with a macrophage
9Overview of Immune System
10MHC interactions
11Response to Ag (humoral system)
12Response to Ag (CMI system)
13Electrophoresis of serum proteins
14Generic Ab
15Ribbon diagram of a monoclonal ab
16Light chain ribbon diagram
17IgG
18Variability of residues in different abs. The 3
hypervariable regions are termed
complementarity- determining regions (CDR)
19Side-view of Angiotensin II bound to Fab.
Van der Waals surface contacts
20A peptide fomr the HIV protease with an
anti-protease Fab
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23 Ab classes
24Antigenic determinants of Abs
25The Ig superfamily
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27B cell development
28 Organization and Expression of Ig Genes
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30(human chromosome 22)
(human chromosome 2)
(human chromosome 14)
Gene arrangements
31Circular DNA isolated from thymocytes undergoing
TCR rearrangement (these rearrange just like Ab
genes)
32From Hozumi and Tonegawa, 1976, PNAS USA 73 3628
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35Kappa gene expression
36H-gene expression
37Recombination signal sequences
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45When ss DNA is generated
Extra nucleotides can also be added
Nucleotide addition during joining
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47 Somatic variation
48Allelic exclusion (only in B and T cells)
49Model of allelic exclusion
50Class switching
51Secreted vs. membrane forms of IgM
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53Class switching by alternative processing
54Class switching by alternative processing
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57Secretory pathway
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59cis-acting sites