Xenobiotics

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Xenobiotics

• Definition A compound that is foreign to the
  body
• Drugs - warfarin
• Chemical Carcinogens - aflatoxin
• Environmental Pollutants - polychlorinated
  biphenyls (PCBs)

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Aflatoxins

• Naturally occurring carcinogen
• Product of a fungus (Aspergillus flavus)
• Found on Corn and other crops throughout the
  world
• One of the most potent carcinogens known and a
• human carcinogen based on epidemiological
  studies

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Metabolism of Aflatoxin
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Rapid Detoxication of Aflatoxiin Epoxide
by Glutathione Transferase makes mice refactory
to carcinogenic effects of this compound.