ANTIMICROBIAL DRUGS'

1
ANTIMICROBIAL DRUGS.

• Introduction.

2
KEY TERMS.

• Chemotherapy.
• Antimicrobial drugs.
• Selective Toxicity.
• Antibiosis.
• Antibiotic.

3
SPECTRUM ANTI-MICROBIAL ACTIVITY.

• Narrow Spectrum.
• Broad Spectrum.
• Superinfection.

4
ANTIMICROBIAL ACTION OF DRUGS.

• Inhibition of cell wall synthesis Penicillin.
• Inhibition of protein synthesis Chloramphenicol.
• Injury to the plasma membrane Polymyxin B.
• Inhibition of nucleic acid synthesis Rifampin.

5

• Inhibiting the synthesis of essential
  metabolites Sulfanilamide.

6
INHIBITORS CELLWALL SYNTHESIS Penicillins.

• Penicillin(Natural).
• Semisynthetic penicillins.
• Monobactams.
• Cephalosporins.
• Carbapenems.
• Bacitracin, Vancomycin.
• Isoniazid,Ethambutol.

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IINHIBITORS OF PROTEIN SYNTHESIS.

• Aminoglycosides.
• Tetracyclines.
• Chloramphenicol.
• Macrolides.

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INJURY TO THE PLASMA MEMBRANE.

• Bacitracin.
• PolymyxinB.

9
INHIBITORS OF DNA/RNA SYNTHESIS.

• Rifamycins.
• Quinolones and Flouroquinolones.

10
Competitive Inhibitors of Synthesis of
Essentials.

• Sufanomides.