Adenosine

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Bronchodilators
Adenosine
Bronchoconstriction
Adenosine Receptor
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Corticoids
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Aminoglutethimide
21-ß-hydoxylase deficiency most common (95 of
cases)
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Cortisol binds MR and GR with equal
affinity Cortisone has minimal MR affinity
Regulation of 10-20 of all genes
GR
GR low affinity, high capacity 2 types hGRa
(classic) and hGRß (inhibitory)
MR high affinity, low capacity
(from PVN)
RAS renin-angiotensin system
Binds to GR receptor in cytosol displacing Hsp 90
and forms dimer
GR
Hsp 90
(ACTH acts via increased cAMP)
Cortisol
Cortisone
Cortisol binds tightly to CBG (cortisol binding
globulin) and loosely to albumin, note that CBG
increases in response to estrogen (pregnancy),
and hyperthryoidism ? it decreases in response to
hypothyroid and protein deficiency NOTE CBG does
not bind synthetic steroids while albumin does
11-ß-hydroxysteroid dehydrogenase
MR
Limbic System
11-ß-hydroxysteroid DH enzyme located near MR
to prevent Cortisol from binding, and preventing
MR over-stimulation
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I dont know if this is testable or not
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Aprotinin
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Bradykinin half life of seconds, Kallidin can
be converted to bradykinin by aminopeptidases and
this form predominates in urine Aprotinin
available in Europe to treat pancreatic cancer
and carcinoid syndrome, now used to inhibit
systemic inflammatory response in CABG
HMWK, LMWK synthesized by the liver, plasma
15 HMWK 85 LMWK, tissue all LMWK ACE
greater affinity for bradykinin than
AngII Removal of an arg decreases affinity for B2
and gains B1