Title: Lipids McM chapt 27
1Lipids (McM chapt 27)
- Naturally occuring, lipophilic comp.
- Wax, fat oils
- Soaps
- Phopholipids
- Prostaglandins
- Terpenoids
- Stereoids
Wax, fat, oils Derivatives of fatty acids
(carboxylic acids)
Wax esters between fatty acid and long chain
alchohol
2Fat (solid), oil (liquid) - Soaps
Basic ester hydrol. - Saponifications
Ca 2 - Hard water Ca(OCOR)2 (s) Cationic
soaps
3Phospholipids
4Prostaglandins etc
Subtypes COX COX-1 Synth of essential
prostagland. COX-2 Active only under inflamations
COX2 inhibitors Coxibes
Rofecoxib Vioxx
COX2/COX2 35
Avreg 2004
5Terpenoids
C-10 Monoterpenes C-15 Sesquiterpenes C-20
Diterpenes C-25 Sesterterpenes C-30 Triterpenes
6(No Transcript)
7Stereoids
B / C og C / D always trans
Sex Hormones
8Estrogens
Corticostereoids
Mineralcorticoid
Glucocorticoid
Effect on metabolism (karbohydrates, lipids,
proteins) Antiinflammatoric
Aldosterone Regulation of elektrolyttic
ballance increase re-uptake of Na (and hence H20)
Numerous semisynth. analogs as drugs Various
antiinflam. activity, mineralcorticoid side
effects
9Corticostereoids
Glucocorticoid
Mineralcorticoid
Effect on metabolism (karbohydrates, lipids,
proteins) Antiinflammatoric
Aldosterone Regulation of elektrolyttic
ballance increase re-uptake of Na (and hence H20)
Numerous semisynth. analogs as drugs Various
antiinflam. activity, mineralcorticoid side
effects