high%20quality%20glass%20columns

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Kronlab Glass Columns

• high quality glass columns
• for lab scale to process scale
• solvent resistant and/or biocompatible design
• designed for low, medium and high pressure column
  chromatography

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Product Lines

• Eco
• lab scale
• low / medium pressure
• ECOPLUS
• extended pressure rating up to 80 bar
• lab scale to prep
• Classic
• lab scale
• medium pressure
• conical tube

• BioCart
• lab scale to prep
• glass cartridges
• medium to high pressure
• Pilot
• pilot scale to production scale
• custom designed
• solvent resistant or for aqueous buffers

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Pilot Columns for Pilot to Production Scale
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Pilot Columns for Pilot to Production Scale

• designed for use in pilot and production scale
• designed for use with organic solvents (version
  SR) or aqueous buffers (version AB)
• outstanding flow distribution for a linear flow
  distribution profile
• high precision manufacturing of plungers and
  distribution plates with CNC milling machines, no
  injection moulding involved

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Pilot Columns for Pilot to Production Scale

• full documentation for validation
• full service and support for custom designed
  columns
• materials are in compliance with FDA regulations
  CFR 21, certified if needed
• precise and reliable height adjustment of the
  piston with hand wheels
• mounted either on castors or fixed stand or
  directly into customers plant

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Pilot Columns - Wetted Materials

• column tube calibrated borosilicate glass or
  stainless steel (steel quality to customers
  specification) optional acrylic
• piston PE, PTFE, PVDF or stainless steel
• seals EPDM or Kalrez
• frits PE, stainless steel, others on request

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Pilot Columns - Sizes

• columns from 60 mm to 600 mm ID
• length on demand

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Pilot Column -Design of Flow Distributor
flow distribution profile proofed by Bayer AG and
Kronlab GmbH
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Pilot Column -flexible inner diameters

PI 450
PI 60
PI 140
PI 100 Cooling Jacket
PI 100
Flow distribution profile proofed by Bayer AG and
Kronlab GmbH
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Pilot Column -flexible column material

stainless steel
glass or acrylic
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Pilot Column -flexible pressure ranges
50 bar
8,7 bar
10 bar
1 bar
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Pilot Column -integration of user demands
e.g. rotable frames, integrated level indicator,
brackets, selected materials, connectors .
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Pilot Columns - Custom Design

• special solutions for individual needs regarding
• materials
• design
• size
• system integration

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Pilot Columns - Custom Design

• individual feasibility studies and technical
  drawings
• certification
• competent guidance throughout the whole project

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Pilot AB - rotatable
column id 200 mm max. bed height 1600
mm pressure rating 7 bar specially designed
rotatable frame construction
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Pilot SR solvent resistant
technical specifications column id 200 and
300 mm max. bed height 400 mm pressure
rating 1.5 bar explosion-proof environment with
antistatic protection and wheels
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Pilot SR stainless steel
technical specifications column id 100
mm max. bed height 1000 mm min bed height 500
mm pressure rating 40 bar sealing Kalrez
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Pilot SR stainless steel
technical specifications column id 150
mm max. bed height 900 mm min bed height 700
mm pressure rating 50 bar sealing Kalrez
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Pilot AB - Reactor

• id 300 mm
• bed height 0- 500 mm
• pressure rating 1 bar
• frit 30 µm
• (SS 1.4404)
• special features
• slurry inlet
• integrated magnetic stirrer on
• cambered bottom frit
• piston with scraper
• special designed column stand

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Pilot AB -rotatable
id 240 mm bed height 0 - 270 mm volume 0-12
l pressure rating 3 bar cooling jacket 15 -
65C SS - container 15 l for slurry
waste frits 10 µm PE 5 mm thicknessspecially
designed frit fastening screwsto ensure perfect
flow distribution
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Pilot Columns - stainless steel
id 600 mm max. bed height 1000 mm (1500
mm) bed volume 282,6 l (423,9 l) pressure
rating 10 bar frits 10 µm
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Pilot Column - stainless steel
Example
id 600 mm max. bed height 1000 mm (1500
mm) bed volume 282,6 l (423,9 l) pressure
rating 10 bar frits 10 µm
designed for repeated packing and unpacking
without opening the column
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Solvent Inlet
Example
Slurry-Inlet through separate slurry pump
Slurry-Outlet through central outlet valve
Solvent Outlets
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Pilot Columns - References

• Abbott
• Aventis
• Baxter Hyland Immuno AG
• Bayer AG
• Biotest
• Clariant
• Genetics Institute
• Genzyme
• Honeywell
• Novartis AG
• Schering AG
• Roche Diagnostics
• etc