Structure - PowerPoint PPT Presentation

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Structure

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Populations designated by Structure are in H-W equilibrium. Real ... Steps through parameter space to estimate the probability that predicted 'K' = actual 'K' ... – PowerPoint PPT presentation

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Title: Structure


1
Structure
  • Infer population structure
  • Assign individuals to populations
  • Identify migrants
  • Identify admixed individuals

2
How it works
  • Populations designated by Structure are in H-W
    equilibrium
  • Real population structure leads to LD and
    departures from H-W
  • Can handle linked markers with linkage map
  • Uses MCMC
  • Starts from a random configuration
  • Steps through parameter space to estimate the
    probability that predicted K actual K

3
Ancestry Models
  • No admixture
  • Use for dominant data
  • Admixture
  • Use for most codominant data
  • An individual may have ancestors in more than one
    population
  • Linkage
  • Use if loci are linked and a linkage map is
    available
  • Likely to occur in recently mixed populations
  • Prior information

4
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5
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6
Determining populations
Codominant data set Pop1MEN Pop2 PLU Pop3
SANB
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